Centrally administered leumorphin possesses potent depressor activity in conscious rats.

H. Itoh; K. Nakao; T. Yamada; N. Morii; S. Shiono; M. Sakamoto; A. Sugawara; Y. Saito; G. Katsuura; T. Shiomi

Centrally administered leumorphin possesses potent depressor activity in conscious rats.

H. Itoh, K. Nakao, T. Yamada, N. Morii, S. Shiono, M. Sakamoto, A. Sugawara, Y. Saito, G. Katsuura, T. Shiomi

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of intracerebroventricular (i.c.v.) administration of leumorphin on basal blood pressure and angiotensin II (AII)-stimulated increase in blood pressure was examined in conscious unrestrained rats. The i.c.v. injection of leumorphin (0.06 and 0.6 nmol) elicited significant depressor effect. The i.c.v. administration of leumorphin with AII (0.1 nmol) significantly attenuated the AII-induced pressor response and, furthermore, lowered blood pressure below the basal level. These results suggest that leumorphin is involved in the central control of blood pressure.

Original language	English
Pages (from-to)	512-515
Number of pages	4
Journal	NIDA research monograph
Volume	75
Publication status	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)

Cite this

@article{ce2d00bfcc3244aa9ddcd3f3c8710d32,

title = "Centrally administered leumorphin possesses potent depressor activity in conscious rats.",

abstract = "The effect of intracerebroventricular (i.c.v.) administration of leumorphin on basal blood pressure and angiotensin II (AII)-stimulated increase in blood pressure was examined in conscious unrestrained rats. The i.c.v. injection of leumorphin (0.06 and 0.6 nmol) elicited significant depressor effect. The i.c.v. administration of leumorphin with AII (0.1 nmol) significantly attenuated the AII-induced pressor response and, furthermore, lowered blood pressure below the basal level. These results suggest that leumorphin is involved in the central control of blood pressure.",

author = "H. Itoh and K. Nakao and T. Yamada and N. Morii and S. Shiono and M. Sakamoto and A. Sugawara and Y. Saito and G. Katsuura and T. Shiomi",

note = "Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",

year = "1986",

language = "English",

volume = "75",

pages = "512--515",

journal = "NIDA research monograph",

issn = "1046-9516",

publisher = "National Institute on Drug Abuse",

}

TY - JOUR

T1 - Centrally administered leumorphin possesses potent depressor activity in conscious rats.

AU - Itoh, H.

AU - Nakao, K.

AU - Yamada, T.

AU - Morii, N.

AU - Shiono, S.

AU - Sakamoto, M.

AU - Sugawara, A.

AU - Saito, Y.

AU - Katsuura, G.

AU - Shiomi, T.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 1986

Y1 - 1986

N2 - The effect of intracerebroventricular (i.c.v.) administration of leumorphin on basal blood pressure and angiotensin II (AII)-stimulated increase in blood pressure was examined in conscious unrestrained rats. The i.c.v. injection of leumorphin (0.06 and 0.6 nmol) elicited significant depressor effect. The i.c.v. administration of leumorphin with AII (0.1 nmol) significantly attenuated the AII-induced pressor response and, furthermore, lowered blood pressure below the basal level. These results suggest that leumorphin is involved in the central control of blood pressure.

AB - The effect of intracerebroventricular (i.c.v.) administration of leumorphin on basal blood pressure and angiotensin II (AII)-stimulated increase in blood pressure was examined in conscious unrestrained rats. The i.c.v. injection of leumorphin (0.06 and 0.6 nmol) elicited significant depressor effect. The i.c.v. administration of leumorphin with AII (0.1 nmol) significantly attenuated the AII-induced pressor response and, furthermore, lowered blood pressure below the basal level. These results suggest that leumorphin is involved in the central control of blood pressure.

UR - http://www.scopus.com/inward/record.url?scp=0022822316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022822316&partnerID=8YFLogxK

M3 - Article

C2 - 3123970

AN - SCOPUS:0022822316

SN - 1046-9516

VL - 75

SP - 512

EP - 515

JO - NIDA research monograph

JF - NIDA research monograph

ER -

Centrally administered leumorphin possesses potent depressor activity in conscious rats.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this