Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy

Takato Abe, Shigeru Nogawa, Norio Tanahashi, Junichi Shiraishi, Eiji Ikeda, Norihiro Suzuki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A 34-year-old woman with hyperthyroidism, who had been previously treated with propylthiouracil (PTU) is reported. She was admitted because of clumsiness in her left hand and abnormal behavior. A neurological examination demonstrated impairment of higher cortical function, and weakness and hyperreflexia of the left leg. An MRI scan with gadolinium enhancement showed pachyleptomeningeal thickening in the right fronto-parietal lobe. Blood tests revealed a high MPO-ANCA titer of 122 EU (normal:<10 EU). After steroid administration, the neurological symptoms and the MRI findings improved markedly. This is the first report of PTU-induced cerebral pachyleptomeningitis associated with a high serum MPO-ANCA titer.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalInternal Medicine
Issue number5
Publication statusPublished - 2007 Mar 1
Externally publishedYes


  • PTU
  • Pachyleptomeningitis

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy'. Together they form a unique fingerprint.

Cite this