TY - JOUR
T1 - Changes in capsule and drug resistance of pneumococci after introduction of PCV7, Japan, 2010-2013
AU - Chiba, Naoko
AU - Morozumi, Miyuki
AU - Shouji, Michi
AU - Wajima, Takeaki
AU - Iwata, Satoshi
AU - Ubukata, Kimiko
PY - 2014/7
Y1 - 2014/7
N2 - We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.
AB - We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.
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UR - http://www.scopus.com/inward/citedby.url?scp=84902821063&partnerID=8YFLogxK
U2 - 10.3201/eid2007.131485
DO - 10.3201/eid2007.131485
M3 - Article
C2 - 24960150
AN - SCOPUS:84902821063
SN - 1080-6040
VL - 20
SP - 1132
EP - 1139
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 7
ER -
