Changes in Muscle Shear Modulus and Urinary Titin N-Terminal Fragment after Eccentric Exercise

Takayuki Inami, Shota Yamaguchi, Hiroyuki Ishida, Naohiko Kohtake, Akihisa Morito, Satoshi Yamada, Masatsugu Shimomasuda, Maki Haramoto, Naoya Nagata, Mitsuyoshi Murayama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


This study aimed to investigate the relationship between the muscle shear modulus of the biceps brachii, urinary titin N-terminal fragment (UTF), and other damage markers after eccentric exer-cise. Seventeen healthy males performed five sets of ten eccentric exercises with dumbbells weighing 50% of the maximum voluntary contraction (MVC) at the elbow joint. Muscle shear modulus with range of interest set to only biceps brachii muscle measured by ultrasound shear wave elastography, UTF, MVC, range of motion (ROM), and soreness (SOR) were recorded before, immedi-ately after, and 1, 24, 48, 72, 96, and 168 h after eccentric exer-cise. Each marker changed in a time course pattern, as found in previous studies. The peak shear modulus showed a moderate negative correlation with peak MVC (r = –0.531, P < 0.05) and a strong positive correlation with peak UTF (r = 0.707, P < 0.01). Our study results revealed a significant relationship between muscle strength, shear modulus measured by ultrasound SWE, and titin measured by UTF, as a non-invasive damage marker after eccentric exercise to track changes in EIMD.

Original languageEnglish
Pages (from-to)536-544
Number of pages9
JournalJournal of Sports Science and Medicine
Issue number4
Publication statusPublished - 2022 Dec


  • Shear wave elastography
  • exercise-induced muscle damage
  • non-invasive method
  • sarcomere
  • stiffness

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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