TY - JOUR
T1 - Changes in plasma endothelin in patients undergoing cardiac valve replacement under high dose fentanyl anesthesia
AU - Takino, Y.
AU - Kondo, M.
AU - Kaneda, T.
AU - Okamoto, Y.
AU - Morisaki, H.
AU - Sato, M.
PY - 1991
Y1 - 1991
N2 - We measured plasma endothelin (ET) in 11 patients undergoing cardiac valve replacement under high dose fentanyl (116.6 ± 15.4 μg · kg-1, mean ± SD) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) just before the start of cardiopulmonary bypass (CPB), and 3) just before the end of CPB. Endothelin levels were analyzed by radioimmunoassay based on double antibody method using Silica ODS suspension. ET concentrations in period 1, 2, and 3 were 3.0 ± 1.1, 4.2 ± 1.7 and 4.5 ± 1.8 pg · ml-1 (mean ± SD), respectively. There were no significant differences among these three values (P < 0.05). The results suggest that under high dose fentanyl anesthesia, surgical stress including that of CPB might not affect ET concentration in plasma.
AB - We measured plasma endothelin (ET) in 11 patients undergoing cardiac valve replacement under high dose fentanyl (116.6 ± 15.4 μg · kg-1, mean ± SD) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) just before the start of cardiopulmonary bypass (CPB), and 3) just before the end of CPB. Endothelin levels were analyzed by radioimmunoassay based on double antibody method using Silica ODS suspension. ET concentrations in period 1, 2, and 3 were 3.0 ± 1.1, 4.2 ± 1.7 and 4.5 ± 1.8 pg · ml-1 (mean ± SD), respectively. There were no significant differences among these three values (P < 0.05). The results suggest that under high dose fentanyl anesthesia, surgical stress including that of CPB might not affect ET concentration in plasma.
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M3 - Article
C2 - 1942512
AN - SCOPUS:0026005677
SN - 0021-4892
VL - 40
SP - 1384
EP - 1386
JO - Japanese Journal of Anesthesiology
JF - Japanese Journal of Anesthesiology
IS - 9
ER -