Changes in regional cerebral blood flow following antidepressant treatment in late-life depression

Junko Ishizaki, Hideki Yamamoto, Taro Takahashi, Maki Takeda, Madoka Yano, Masaru Mimura

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Objective: Reversible/irreversible abnormalities of regional cerebral blood flow (rCBF) are seen in patients with depression. However, in late-life depression there is little evidence of a longitudinal change in rCBF through remission. We examined whether the decreased rCBF in individuals with late-life depression resolves following treatment. Methods: Twenty-five depressed patients older than 55 years completed the Hamilton Rating Scale for Depression and single photon emission computed tomography before and after a mean of 13.7 weeks of pharmacotherapy. Quantitative analyses were performed using the Statistical Parametric Mapping procedure. Results: Patients with depression demonstrated decreased rCBF in the anterior ventral and dorsal medial prefrontal cortex (PFC), including anterior cingulate cortices, bilateral ventrolateral PFC to temporal cortices, and bilateral medial to lateral parieto-occipital lobes relative to healthy controls. No particular areas showed increased rCBF. Following pharmacotherapy, rCBF significantly increased in the left dorsolateral PFC to precentral areas and the right parieto-occipital regions. However, decreased rCBF at baseline in the anterior ventral/ dorsal medial PFC, bilateral ventrolateral PFC, bilateral temporal lobes, and bilateral parietal lobes did not show significant improvement after treatment. Conclusions: Remarkable improvements in rCBF in the left dorsolateral PFC to precentral regions are consistent with the hypothesis that neuronetworks including the left frontal cortex may be functionally and reversibly involved in late-life unipolar major depression (state-dependent). In contrast, neural circuits including bilateral medial, dorsolateral, and parietal areas may reflect underlying and continuous pathognomonic brain dysfunction of depression (trait-dependent).

Original languageEnglish
Pages (from-to)805-811
Number of pages7
JournalInternational Journal of Geriatric Psychiatry
Issue number8
Publication statusPublished - 2008 Aug 1
Externally publishedYes


  • Frontal lobe
  • Late-life
  • Vascular depression

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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