Changes of β-1,4-galactosyltransferase with the development of endometrial cancer

Kaneyuki Kubushiro; Jun Ma; Takeshi Fukuchi; Kouji Banno; Yuko Muramatsu; Katsumi Tsukazaki; Shiro Nozawa

doi:10.1159/000010158

Changes of β-1,4-galactosyltransferase with the development of endometrial cancer

Kaneyuki Kubushiro, Jun Ma, Takeshi Fukuchi, Kouji Banno, Yuko Muramatsu, Katsumi Tsukazaki, Shiro Nozawa

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of β-1,4-galactosyltransferase (β-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that β-1,4GT was diffusely positive in the cytoplasm of endometrial cancer cells, and that the level of its expression was increased compared with that in normal endometrium. Also, β-1,4GT mRNA corresponding to 4.7 kb was very low in normal endometrium, while an intense signal was detected in endometrial cancer. Our results suggest that the increase of β-1,4GT contributes to the expression of the type 2 carbohydrate chain in endometrial cancer.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	Gynecologic and Obstetric Investigation
Volume	48
Issue number	3
DOIs	https://doi.org/10.1159/000010158
Publication status	Published - 1999

Keywords

Carbohydrate chain, type 2
Endometrial cancer
β-1,4-galactosyltransferase

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000010158

Cite this

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abstract = "To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of β-1,4-galactosyltransferase (β-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that β-1,4GT was diffusely positive in the cytoplasm of endometrial cancer cells, and that the level of its expression was increased compared with that in normal endometrium. Also, β-1,4GT mRNA corresponding to 4.7 kb was very low in normal endometrium, while an intense signal was detected in endometrial cancer. Our results suggest that the increase of β-1,4GT contributes to the expression of the type 2 carbohydrate chain in endometrial cancer.",

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T1 - Changes of β-1,4-galactosyltransferase with the development of endometrial cancer

AU - Kubushiro, Kaneyuki

AU - Ma, Jun

AU - Fukuchi, Takeshi

AU - Banno, Kouji

AU - Muramatsu, Yuko

AU - Tsukazaki, Katsumi

AU - Nozawa, Shiro

PY - 1999

Y1 - 1999

N2 - To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of β-1,4-galactosyltransferase (β-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that β-1,4GT was diffusely positive in the cytoplasm of endometrial cancer cells, and that the level of its expression was increased compared with that in normal endometrium. Also, β-1,4GT mRNA corresponding to 4.7 kb was very low in normal endometrium, while an intense signal was detected in endometrial cancer. Our results suggest that the increase of β-1,4GT contributes to the expression of the type 2 carbohydrate chain in endometrial cancer.

AB - To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of β-1,4-galactosyltransferase (β-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that β-1,4GT was diffusely positive in the cytoplasm of endometrial cancer cells, and that the level of its expression was increased compared with that in normal endometrium. Also, β-1,4GT mRNA corresponding to 4.7 kb was very low in normal endometrium, while an intense signal was detected in endometrial cancer. Our results suggest that the increase of β-1,4GT contributes to the expression of the type 2 carbohydrate chain in endometrial cancer.

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KW - β-1,4-galactosyltransferase

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Changes of β-1,4-galactosyltransferase with the development of endometrial cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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