Changing trends in the treatment of dry-eye disease

Murat Dogru, Masatsugu Nakamura, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)


Introduction: Dry eye is a visually disabling disease encountered in many countries with a wide variation of treatment practices all over the world. On that front, the 2007 Report of the International Dry Eye WorkShop (DEWS) reviewed the current knowledge on all aspects of dry-eye disease (DED), in an evidence-based manner, and outlined the trends and recommendations in the treatment of DED on the basis of disease severity. Areas covered: This review mainly focuses on treatments for DED based on severity as recommended in the DEWS report, particularly artificial eye drops, hyaluronate sodium eye drops, autologous serum, anti-inflammatory eye drops including cyclosporine and steroids, and mucin secretagogues. New dry-eye treatment modalities in current trials outlined on the site are also outlined. Expert opinion: Further investigations into the mechanism of action of the new mucin and tear secretagogues which have been suggested to have anti-inflammatory properties will enrich our understanding in relation to relevant ocular surface responses after treatment with these new agents.

Original languageEnglish
Pages (from-to)1581-1601
Number of pages21
JournalExpert Opinion on Investigational Drugs
Issue number12
Publication statusPublished - 2013 Dec
Externally publishedYes


  • Artificial eye drops
  • Autologous serum
  • Dry-eye disease
  • Mucin secretagogues
  • Tear secretagogues

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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