Characterisation of neural crest-derived stem cells in different tissues

Research output: Chapter in Book/Report/Conference proceedingChapter


A burst of recent findings has shown that neural crest-derived stem cells (NCSCs) reside in diverse mammalian tissues. In addition to tissues known to be derived from the neural crest, recent studies show that NCSCs exist in tissues that are not neural crest-derived, such as bone marrow. Although how NCSCs are defined has varied among reports to date, it is clear that NCSCs can self-renew and have the potential to differentiate into several different neural-crest lineages, including neurons, glial cells, myofibroblasts, melanocytes, adipocytes, chondrocytes, osteocytes, and connective tissues (Crane & Trainor, 2006; Delfino-Machin et al., 2007). NCSCs can express a wide range of characteristics, with their specific properties mainly depending on their tissue source and the animal’s ontogenic stage. The identification of NCSCs in this wide variety of tissues opens an entirely new approach for developing autologous cell replacement therapies for use in regenerative medicine.

Original languageEnglish
Title of host publicationNeural Crest Stem Cells
Subtitle of host publicationBreakthroughs and Applications
PublisherWorld Scientific Publishing Co.
Number of pages21
ISBN (Electronic)9789814343817
ISBN (Print)9814343803, 9789814343800
Publication statusPublished - 2012 Jan 1

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Engineering


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