Characteristics and mechanism of myocardium tissue laser ablation: In-vitro study for transmyocardial laser revascularization

Shunichi Sato, Tomoaki Shimada, Makoto Ogura, Miya Ishihara, Tsunenori Arai, Takemi Matsui, Akira Kurita, Minoru Obara, Makoto Kikuchi, Hitoshi Wakisaka, Hiroshi Ashida

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)


To investigate the optimum laser condition for transmyocardial laser revascularization (TMLR), ablation characteristics of porcine myocardium tissue have been measured in vitro in the spectral region from UV to near IR (230-1064 nm). In experiments, a nanosecond, tunable optical parametric oscillator (OPO) and a Q-switched Nd:YAG laser (the fundamental band and its 2nd, 3rd, and 4th harmonics) were used for ablation. Measurement of ablation hole depth and diameter, and histological analysis with an optical microscope were performed. It was found that the ablation efficiency increased and the thermal damage thickness of the tissue decreased with decreasing the wavelength. However, at relatively high fluences (approximately 5 J/cm2), unexpected deep ablation was obtained with a 1064-nm laser light, where not thermal but acoustic damage was observed near the walls of the ablation holes. Because intense laser-induced plasma was observed in this case, the shock wave would contribute to removal and/or damage of the tissue.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2000
Externally publishedYes
EventHigh-Power Laser Ablation II - Osaka, Jpn
Duration: 1999 Nov 11999 Nov 5

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Characteristics and mechanism of myocardium tissue laser ablation: In-vitro study for transmyocardial laser revascularization'. Together they form a unique fingerprint.

Cite this