Characteristics of 18 patients with hepatocellular carcinoma who obtained a complete response after treatment with sorafenib

Satoshi Shiba, Takuji Okusaka, Masafumi Ikeda, Hidetsugu Saito, Takafumi Ichida

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21 Citations (Scopus)


Aim: Sorafenib, a multi-targeted tyrosine kinase inhibitor, is a first-line systemic treatment for advanced hepatocellular carcinoma (HCC). However, possible predictors of the efficacy of sorafenib treatment in HCC patients remain unclear. Methods: We conducted a nationwide survey to examine the situation of patients with HCC treated with sorafenib who obtained a complete response (CR) according to the modified response evaluation criteria in solid tumors (mRECIST). The investigation was intended to collect clinical information regarding CR patients and to compare this data with an interim report examining all-patient surveillance for sorafenib use in Japan, which was released in May 2012. Results: Among the 3047 patients who were treated at institutions belonging to the Liver Cancer Study Group of Japan, 18 patients (0.6%) obtained a CR. Significant factors in the CR group were a female sex, a low bodyweight (<59kg), an early clinical stage and a small initial dose of sorafenib (P<0.05). Furthermore, specific adverse events (palmar-plantar erythrodysesthesia syndrome, hypertension, diarrhea, alopecia, fatigue, nausea and anorexia) were frequently observed in the CR group (P<0.05). Conclusion: This study identified the characteristics of CR patients during sorafenib treatment. The evaluation of patients receiving sorafenib, including the investigation of biomarkers, warrants further exploration in future clinical studies to identify a population in which sorafenib treatment is remarkably effective.

Original languageEnglish
Pages (from-to)1268-1276
Number of pages9
JournalHepatology Research
Issue number13
Publication statusPublished - 2014 Jan 1


  • Adverse drug event
  • Complete response
  • Data collection
  • Hepatocellular carcinoma
  • Population characteristics
  • Sorafenib

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases


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