TY - JOUR
T1 - Characterization of a Novel Acidic Polysaccharide with Immunological Activities from the Rhizome of Cnidium officinale
AU - Ohara, Naoko
AU - Shimizu, Noriko
AU - Gonda, Ryoko
AU - Tomoda, Masashi
PY - 1994
Y1 - 1994
N2 - An acidic polysaccharide, called cnidirhan SIIB, was isolated from the rhizome of Cnidium officinale Makino. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.9 x 104. It was composed of L-arabinose, D-galactose and D-galacturonic acid in the molar ratio of 9:11:3, in addition to a few 0-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation studies indicated that its structural features are composed primarily of α-L-arabino-β-3,6- and 3,4-branched D-galactan type units. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test and marked anti-complementary activity.
AB - An acidic polysaccharide, called cnidirhan SIIB, was isolated from the rhizome of Cnidium officinale Makino. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.9 x 104. It was composed of L-arabinose, D-galactose and D-galacturonic acid in the molar ratio of 9:11:3, in addition to a few 0-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation studies indicated that its structural features are composed primarily of α-L-arabino-β-3,6- and 3,4-branched D-galactan type units. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test and marked anti-complementary activity.
KW - Cnidium officinale
KW - acidic arabinogalactan
KW - cnidirhan SIIB
KW - immunological activity
KW - polysaccharide structure
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U2 - 10.1248/cpb.42.1886
DO - 10.1248/cpb.42.1886
M3 - Article
AN - SCOPUS:0028126907
SN - 0009-2363
VL - 42
SP - 1886
EP - 1889
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 9
ER -