Abstract
An acidic polysaccharide, named glycyrrhizan GA, was isolated from the stolon of Glycyrrhiza glabra L. var. glandulifera reg.etherd. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 85000. Glycyrrhizan GA is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid:D-glucuronic acid in the molar ratio of 22:10:1:2:1, in addition to small amounts of 0-acetyl groups. Part of the hexuronic acid residues exist as methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated that its structural features include mainly a-arabino-/l-3,6-galactan type structural units. Glycyrrhizan GA showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test.
| Original language | English |
|---|---|
| Pages (from-to) | 2082-2086 |
| Number of pages | 5 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 39 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1991 |
Keywords
- Keywords Glyeyrrhiza glabra var. glandulifera
- acidic arabinogalactan
- glycyrrhizan GA
- immunological activity
- licorice
- polysaccharide
- reticuloendothelial system
- stolon
- structural features
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery