Characterization of Polysaccharides Having Activity on the Reticuloendothelial System from the Rhizome of Curcuma longa

Ryoko Gonda; Masashi Tomoda; Noriko Shimizu; Mieko Kanari

doi:10.1248/cpb.38.482

Characterization of Polysaccharides Having Activity on the Reticuloendothelial System from the Rhizome of Curcuma longa

Ryoko Gonda, Masashi Tomoda, Noriko Shimizu, Mieko Kanari

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Three polysaccharides, named ukonan A, ukonan B and ukonan C, were isolated from the rhizomes of Curcuma longa L. They were homogeneous on electrophoresis and gel chromatography, and showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. They are composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratios of 12:4:12:1:4:10 (ukonan A), 12:4:12:1:2:4 (ukonan B) and 8:3:6:14:2:3 (ukonan C), in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated the structural features of ukonan B, the major one in terms of the activity. It has acidic arabino-galactan type structural units.

Original language	English
Pages (from-to)	482-486
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	38
Issue number	2
DOIs	https://doi.org/10.1248/cpb.38.482
Publication status	Published - 1990

Keywords

Curcuma longa
acidic arabinogalactan
immunological activity
methylation analysis
polysaccharide structure
reticuloendothelial system
rhizome
turmeric
ukonan B

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Characterization of Polysaccharides Having Activity on the Reticuloendothelial System from the Rhizome of Curcuma longa",

abstract = "Three polysaccharides, named ukonan A, ukonan B and ukonan C, were isolated from the rhizomes of Curcuma longa L. They were homogeneous on electrophoresis and gel chromatography, and showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. They are composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratios of 12:4:12:1:4:10 (ukonan A), 12:4:12:1:2:4 (ukonan B) and 8:3:6:14:2:3 (ukonan C), in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated the structural features of ukonan B, the major one in terms of the activity. It has acidic arabino-galactan type structural units.",

keywords = "Curcuma longa, acidic arabinogalactan, immunological activity, methylation analysis, polysaccharide structure, reticuloendothelial system, rhizome, turmeric, ukonan B",

author = "Ryoko Gonda and Masashi Tomoda and Noriko Shimizu and Mieko Kanari",

year = "1990",

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AU - Tomoda, Masashi

AU - Shimizu, Noriko

AU - Kanari, Mieko

PY - 1990

Y1 - 1990

N2 - Three polysaccharides, named ukonan A, ukonan B and ukonan C, were isolated from the rhizomes of Curcuma longa L. They were homogeneous on electrophoresis and gel chromatography, and showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. They are composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratios of 12:4:12:1:4:10 (ukonan A), 12:4:12:1:2:4 (ukonan B) and 8:3:6:14:2:3 (ukonan C), in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated the structural features of ukonan B, the major one in terms of the activity. It has acidic arabino-galactan type structural units.

AB - Three polysaccharides, named ukonan A, ukonan B and ukonan C, were isolated from the rhizomes of Curcuma longa L. They were homogeneous on electrophoresis and gel chromatography, and showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. They are composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratios of 12:4:12:1:4:10 (ukonan A), 12:4:12:1:2:4 (ukonan B) and 8:3:6:14:2:3 (ukonan C), in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated the structural features of ukonan B, the major one in terms of the activity. It has acidic arabino-galactan type structural units.

KW - Curcuma longa

KW - acidic arabinogalactan

KW - immunological activity

KW - methylation analysis

KW - polysaccharide structure

KW - reticuloendothelial system

KW - rhizome

KW - turmeric

KW - ukonan B

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Characterization of Polysaccharides Having Activity on the Reticuloendothelial System from the Rhizome of Curcuma longa

Abstract

Keywords

ASJC Scopus subject areas

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