Characterization of predictors of in-hospital cardiac complications of takotsubo cardiomyopathy: Multi-center registry from Tokyo CCU Network

Tsutomu Murakami, Tsutomu Yoshikawa, Yuichiro Maekawa, Tetsuro Ueda, Toshiaki Isogai, Yuji Konishi, Konomi Sakata, Ken Nagao, Takeshi Yamamoto, Morimasa Takayama

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)


Background: Takotsubo cardiomyopathy (TC) is an acute cardiac syndrome characterized by transient left ventricular dysfunction and relatively good prognosis after discharge. However, cardiac complications during hospitalization remain to be fully determined. We attempted to determine features characterizing patients with adverse clinical outcome by comparing those with cardiac complication and without cardiac complication during hospitalization. Methods and results: We investigated 107 patients with TC from the Tokyo CCU Network database, comprising 67 cardiovascular centers in the metropolitan area during January 1 to December 31, 2010. Cardiac complications were defined as cardiac death, pump failure (Killip grade. ≥. II), sustained ventricular tachycardia or fibrillation (SVT/VF), and advanced atrioventricular block (AVB). Cardiac complications were observed in 41 patients (37 pump failure complicated by 3 cardiac deaths and 2 SVT/VF and 2 AVB without pump failure), and there was no cardiac complication in the remaining 66 patients. There was no difference in age, peak creatinine kinase level, C-reactive protein level and ST elevation on electrocardiogram. Multiple logistic regression analysis showed that white blood cell count ( p= 0.039) and brain natriuretic peptide ( p= 0.001) were independent predictors of in-hospital adverse cardiac complications. Conclusions: Cardiac complications are relatively high in patients with TC during hospitalization. High white blood cell count and brain natriuretic peptide level are associated with poor clinical outcome in patients with TC.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalJournal of Cardiology
Issue number4
Publication statusPublished - 2014 Apr
Externally publishedYes


  • Arrhythmia
  • Heart failure
  • Inflammation
  • Mortality
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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