TY - JOUR
T1 - Characterization of the Structural Diversity and Structure-Specific Behavior of Oxidized Phospholipids by LC-MS/MS
AU - Aoyagi, Ryohei
AU - Yamamoto, Takahiro
AU - Furukawa, Yuuki
AU - Arita, Makoto
N1 - Funding Information:
Acknowledgments This study was supported by the JSPS Grant-in-Aid for Scientific Research on Innovative Areas (KAKENHI 15H05897 and 15H05898 to M.A.), RIKEN Pioneering Project “Glyco-Lipidologue Initiative” (to M.A.), Keio Gijuku Academic Development Funds and Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research (to R.A.).
Publisher Copyright:
© 2021 Pharmaceutical Society of Japan. All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Polyunsaturated fatty acids (PUFAs), esterified to phospholipids, are susceptible to oxidation. They form oxidized phospholipids (OxPLs) by oxygenases or reactive oxygen species (ROS), or both. These OxPLs are associated with various diseases, such as atherosclerosis, pulmonary injuries, neurodegenerative diseases, cancer, and diabetes. Since many types of OxPLs seem to be generated in vivo, precise determination of their structural diversity is required to understand their potential structure-specific functions. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful method to quantitatively measure the structural diversity of OxPLs present in biological samples. This review outlines recent advances in analytical methods for OxPLs and their physiological relevance in health and diseases.
AB - Polyunsaturated fatty acids (PUFAs), esterified to phospholipids, are susceptible to oxidation. They form oxidized phospholipids (OxPLs) by oxygenases or reactive oxygen species (ROS), or both. These OxPLs are associated with various diseases, such as atherosclerosis, pulmonary injuries, neurodegenerative diseases, cancer, and diabetes. Since many types of OxPLs seem to be generated in vivo, precise determination of their structural diversity is required to understand their potential structure-specific functions. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful method to quantitatively measure the structural diversity of OxPLs present in biological samples. This review outlines recent advances in analytical methods for OxPLs and their physiological relevance in health and diseases.
KW - Analytical chemistry
KW - Lipidomics
KW - Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
KW - Oxidized phospholipid
KW - Oxylipin
KW - Polyunsaturated fatty acid
UR - http://www.scopus.com/inward/record.url?scp=85116412248&partnerID=8YFLogxK
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U2 - 10.1248/cpb.c21-00274
DO - 10.1248/cpb.c21-00274
M3 - Review article
C2 - 34602576
AN - SCOPUS:85116412248
SN - 0009-2363
VL - 69
SP - 953
EP - 961
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 10
ER -
