Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules

Kazunobu Toshima; Daisuke Takahashi

doi:10.1007/s10719-015-9591-9

Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules

Kazunobu Toshima, Daisuke Takahashi

Department of Applied Chemistry

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.

Original language	English
Pages (from-to)	475-482
Number of pages	8
Journal	Glycoconjugate Journal
Volume	32
Issue number	7
DOIs	https://doi.org/10.1007/s10719-015-9591-9
Publication status	Published - 2015 Oct 1

Keywords

Anthracene
Anthraquinone
Boronic acid
Kemp's acid
Lectin
Photodegradation

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1007/s10719-015-9591-9

Cite this

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title = "Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules",

abstract = "Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.",

keywords = "Anthracene, Anthraquinone, Boronic acid, Kemp's acid, Lectin, Photodegradation",

author = "Kazunobu Toshima and Daisuke Takahashi",

note = "Funding Information: The authors wish to sincerely thank all of the co-authors of the references cited in this review article. This research was supported in part by Scientific Research (B) (No. 23310153 and 26282212), Scientific Research on Innovative Areas “Chemical Biology of Natural Products” (No. 24102528 and 26102738), and Grants-in-Aid for Young Scientists (B) (No. 22710220) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). Publisher Copyright: {\textcopyright} 2015 Springer Science+Business Media New York.",

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doi = "10.1007/s10719-015-9591-9",

language = "English",

volume = "32",

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journal = "Glycoconjugate Journal",

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T1 - Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules

AU - Toshima, Kazunobu

AU - Takahashi, Daisuke

N1 - Funding Information: The authors wish to sincerely thank all of the co-authors of the references cited in this review article. This research was supported in part by Scientific Research (B) (No. 23310153 and 26282212), Scientific Research on Innovative Areas “Chemical Biology of Natural Products” (No. 24102528 and 26102738), and Grants-in-Aid for Young Scientists (B) (No. 22710220) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). Publisher Copyright: © 2015 Springer Science+Business Media New York.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.

AB - Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.

KW - Anthracene

KW - Anthraquinone

KW - Boronic acid

KW - Kemp's acid

KW - Lectin

KW - Photodegradation

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JO - Glycoconjugate Journal

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Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules

Abstract

Keywords

ASJC Scopus subject areas

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