Chemotherapy for head and neck cancer: Current status and problems in japan

Toshiki Tomita, Yorihisa Imanishi, Hiroyuki Ozawa, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Kaoru Ogawa, Junichi Fukada, Naoyuki Shigematsu, Yasunao Kogashiwa, Kohichi Yamauchi, Naoyuki Kohno

Research output: Contribution to journalArticlepeer-review


A meta-analysis showed that chemoradiotherapy (CCRT) improved survival in patients with advanced head and neck squamous cell carcinoma (HNSCC). CCRT has become widely used in treating such patients. The purpose of CCRT in the treatment of resectable HNSCC is to improve survival while preserving organs and functions, and so CCRT is a potential alternative to surgery. However, problems regarding CCRT were revealed such as severe dysphasia and difficulty of salvage surgery. Recently, induction chemotherapy has attracted attention again, the purpose of which is to predict the response of subsequent CCRT or to improve outcomes. Moreover, chemotherapy is concurrently used with postoperative radiotherapy or definitively used for recurrent or metastatic HNSCC. In this article, we review the current state of chemotherapy for HNSCC and consider the problems in Japan.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalToukeibu Gan
Issue number3
Publication statusPublished - 2010


  • Chemoradiotherapy
  • Chemotherapy
  • Head and neck cancer
  • Induction chemotherapy
  • Multidisciplinary approach

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Oncology


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