Chloroform is not solvent but activator for cobalt complex catalyst of enantioselective borohydride reduction

Ai Kokura; Saiko Tanaka; Haruna Teraoka; Atsushi Shibahrara; Taketo Ikeno; Takushi Nagata; Tohru Yamada

doi:10.1246/cl.2007.26

Chloroform is not solvent but activator for cobalt complex catalyst of enantioselective borohydride reduction

Ai Kokura, Saiko Tanaka, Haruna Teraoka, Atsushi Shibahrara, Taketo Ikeno, Takushi Nagata, Tohru Yamada

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

For the enantioselective borohydride reduction of carbonyl compounds catalyzed by the optically active ketoiminatocobalt complexes, chloroform has been employed as a unique solvent for achieving a high enantioselectivity, whereas it was found that a catalytic amount of chloroform effectively activated the present catalytic system to convert various ketones into the corresponding reduced product with a high ee in the THF solvent.

Original language	English
Pages (from-to)	26-27
Number of pages	2
Journal	Chemistry Letters
Volume	36
Issue number	1
DOIs	https://doi.org/10.1246/cl.2007.26
Publication status	Published - 2007 Jan 5

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2007.26

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abstract = "For the enantioselective borohydride reduction of carbonyl compounds catalyzed by the optically active ketoiminatocobalt complexes, chloroform has been employed as a unique solvent for achieving a high enantioselectivity, whereas it was found that a catalytic amount of chloroform effectively activated the present catalytic system to convert various ketones into the corresponding reduced product with a high ee in the THF solvent.",

author = "Ai Kokura and Saiko Tanaka and Haruna Teraoka and Atsushi Shibahrara and Taketo Ikeno and Takushi Nagata and Tohru Yamada",

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AU - Kokura, Ai

AU - Tanaka, Saiko

AU - Teraoka, Haruna

AU - Shibahrara, Atsushi

AU - Ikeno, Taketo

AU - Nagata, Takushi

AU - Yamada, Tohru

PY - 2007/1/5

Y1 - 2007/1/5

N2 - For the enantioselective borohydride reduction of carbonyl compounds catalyzed by the optically active ketoiminatocobalt complexes, chloroform has been employed as a unique solvent for achieving a high enantioselectivity, whereas it was found that a catalytic amount of chloroform effectively activated the present catalytic system to convert various ketones into the corresponding reduced product with a high ee in the THF solvent.

AB - For the enantioselective borohydride reduction of carbonyl compounds catalyzed by the optically active ketoiminatocobalt complexes, chloroform has been employed as a unique solvent for achieving a high enantioselectivity, whereas it was found that a catalytic amount of chloroform effectively activated the present catalytic system to convert various ketones into the corresponding reduced product with a high ee in the THF solvent.

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Chloroform is not solvent but activator for cobalt complex catalyst of enantioselective borohydride reduction

Abstract

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