TY - JOUR
T1 - Chromatography-free synthesis of Corey's intermediate for Tamiflu
AU - Furutachi, Makoto
AU - Kumagai, Naoya
AU - Watanabe, Takumi
AU - Shibasaki, Masakatsu
N1 - Funding Information:
M.S and M.F. are grateful to Adaptable and Seamless Technology Transfer Program through Target-driven R&D, JST for financial support. The authors appreciate Dr. Shinjiro Sumi, Mr. Hiroyuki Yamaguchi, Mr. Tadashi Ishiyama, and Mr. Shinya Ikeda (Meiji Seika Pharma Co., Ltd.) for their valuable suggestions. The authors thank Ms. Chiharu Sakashita (BIKAKEN) for her technical assistance. The authors are thankful to Dr. Ryuichi Sawa, Ms. Yumiko Kubota, and Ms. Yuko Takahashi (BIKAKEN) for spectroscopic analysis.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014/11/25
Y1 - 2014/11/25
N2 - Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.
AB - Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.
KW - Chromatography-free synthesis
KW - Corey's intermediate
KW - Stereoselective synthesis
KW - Tamiflu
UR - http://www.scopus.com/inward/record.url?scp=84922617426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922617426&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2014.09.081
DO - 10.1016/j.tet.2014.09.081
M3 - Article
AN - SCOPUS:84922617426
SN - 0040-4020
VL - 70
SP - 9113
EP - 9117
JO - Tetrahedron
JF - Tetrahedron
IS - 47
ER -