Chromatography-free synthesis of Corey's intermediate for Tamiflu

Makoto Furutachi; Naoya Kumagai; Takumi Watanabe; Masakatsu Shibasaki

doi:10.1016/j.tet.2014.09.081

Chromatography-free synthesis of Corey's intermediate for Tamiflu

Makoto Furutachi
, Naoya Kumagai
, Takumi Watanabe
, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.

Original language	English
Pages (from-to)	9113-9117
Number of pages	5
Journal	Tetrahedron
Volume	70
Issue number	47
DOIs	https://doi.org/10.1016/j.tet.2014.09.081
Publication status	Published - 2014 Nov 25
Externally published	Yes

Keywords

Chromatography-free synthesis
Corey's intermediate
Stereoselective synthesis
Tamiflu

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tet.2014.09.081

Cite this

@article{6aa0776f26d2418ea1f00c7fe427f17a,

title = "Chromatography-free synthesis of Corey's intermediate for Tamiflu",

abstract = "Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.",

keywords = "Chromatography-free synthesis, Corey's intermediate, Stereoselective synthesis, Tamiflu",

author = "Makoto Furutachi and Naoya Kumagai and Takumi Watanabe and Masakatsu Shibasaki",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

year = "2014",

month = nov,

day = "25",

doi = "10.1016/j.tet.2014.09.081",

language = "English",

volume = "70",

pages = "9113--9117",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "47",

}

TY - JOUR

T1 - Chromatography-free synthesis of Corey's intermediate for Tamiflu

AU - Furutachi, Makoto

AU - Kumagai, Naoya

AU - Watanabe, Takumi

AU - Shibasaki, Masakatsu

PY - 2014/11/25

Y1 - 2014/11/25

N2 - Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.

AB - Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.

KW - Chromatography-free synthesis

KW - Corey's intermediate

KW - Stereoselective synthesis

KW - Tamiflu

UR - https://www.scopus.com/pages/publications/84922617426

UR - https://www.scopus.com/pages/publications/84922617426#tab=citedBy

U2 - 10.1016/j.tet.2014.09.081

DO - 10.1016/j.tet.2014.09.081

M3 - Article

AN - SCOPUS:84922617426

SN - 0040-4020

VL - 70

SP - 9113

EP - 9117

JO - Tetrahedron

JF - Tetrahedron

IS - 47

ER -

Chromatography-free synthesis of Corey's intermediate for Tamiflu

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this