Chromosome aberrations induced by high-LET radiations.

Tetsuya Kawata, Hisao Ito, Kerry George, Honglu Wu, Francis A. Cucinotta

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Measurements of chromosome aberrations in peripheral blood lymphocytes are currently the most sensitive and reliable indicator of radiation exposure that can be used for biological dosimetry. This technique has been implemented recently to study radiation exposures incurred by astronauts during space flight, where a significant proportion of the dose is delivered by high-LET particle exposure. Traditional methods for the assessing of cytogenetic damage in mitotic cells collected at one time point after exposure may not be suitable for measuring high-LET radiation effects due to the drastic cell cycle perturbations and interphase cell death induced by this type of exposure. In this manuscript we review the recent advances in methodology used to study high-LET induced cytogenetic effects and evaluate the use of chemically-induced Premature Chromosome Condensation (PCC) as an alternative to metaphase analysis. Published data on the cytogenetic effects of in vitro exposures of high-LET radiation is reviewed, along with biodosimetry results from astronauts after short or long space missions.

Original languageEnglish
Pages (from-to)216-223
Number of pages8
JournalBiological sciences in space = Uchū seibutsu kagaku
Issue number4
Publication statusPublished - 2004 Dec

ASJC Scopus subject areas

  • General Medicine


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