Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein

Chizuru Ariake; Naoki Hosoe; Hinako Sakurai; Anna Tojo; Yukie Hayashi; Kenji J.L. Limpias Kamiya; Tomohisa Sujino; Kaoru Takabayashi; Kenjiro Kosaki; Satowa Seki; Tadakazu Hisamatsu; Haruhiko Ogata; Takanori Kanai

doi:10.2169/internalmedicine.8939-21

Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein

Chizuru Ariake, Naoki Hosoe, Hinako Sakurai, Anna Tojo, Yukie Hayashi, Kenji J.L. Limpias Kamiya, Tomohisa Sujino, Kaoru Takabayashi, Kenjiro Kosaki, Satowa Seki, Tadakazu Hisamatsu, Haruhiko Ogata, Takanori Kanai

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Chronic enteropathy associated with solute carrier organic anion transporter family, member 2A1 (SLCO2 A1) (CEAS) is a rare autosomal recessive hereditary disease characterized by chronic persistent anemia and hypoproteinemia. Its diagnosis typically requires a genetic analysis. The efficacy of immunohistochemical staining with SLCO2A1 polyclonal antibody as a pre-diagnostic tool for CEAS has been previously reported. We herein report a patient with CEAS in whom immunohistochemical staining confirmed SLCO2A1 protein expression. The immunopositive results may have been due to nonsense-mediated RNA decay. As immunohistochemical staining of SLCO2A1 protein may show immunopositive results, a genetic analysis should also be performed when CEAS is strongly clinically suspected.

Original language	English
Pages (from-to)	2607-2611
Number of pages	5
Journal	Internal Medicine
Volume	61
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.8939-21
Publication status	Published - 2022

Keywords

balloon-assisted enteroscopy
chronic enteropathy associated with SLCO2A1 gene
small intestine
video capsule endoscopy

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.8939-21

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Ariake, C., Hosoe, N., Sakurai, H., Tojo, A., Hayashi, Y., Limpias Kamiya, K. J. L., Sujino, T., Takabayashi, K., Kosaki, K., Seki, S., Hisamatsu, T., Ogata, H., & Kanai, T. (2022). Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein. Internal Medicine, 61(17), 2607-2611. https://doi.org/10.2169/internalmedicine.8939-21

Ariake, C, Hosoe, N, Sakurai, H, Tojo, A, Hayashi, Y, Limpias Kamiya, KJL, Sujino, T , Takabayashi, K , Kosaki, K, Seki, S, Hisamatsu, T, Ogata, H & Kanai, T 2022, 'Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein', Internal Medicine, vol. 61, no. 17, pp. 2607-2611. https://doi.org/10.2169/internalmedicine.8939-21

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title = "Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein",

abstract = "Chronic enteropathy associated with solute carrier organic anion transporter family, member 2A1 (SLCO2 A1) (CEAS) is a rare autosomal recessive hereditary disease characterized by chronic persistent anemia and hypoproteinemia. Its diagnosis typically requires a genetic analysis. The efficacy of immunohistochemical staining with SLCO2A1 polyclonal antibody as a pre-diagnostic tool for CEAS has been previously reported. We herein report a patient with CEAS in whom immunohistochemical staining confirmed SLCO2A1 protein expression. The immunopositive results may have been due to nonsense-mediated RNA decay. As immunohistochemical staining of SLCO2A1 protein may show immunopositive results, a genetic analysis should also be performed when CEAS is strongly clinically suspected.",

keywords = "balloon-assisted enteroscopy, chronic enteropathy associated with SLCO2A1 gene, small intestine, video capsule endoscopy",

author = "Chizuru Ariake and Naoki Hosoe and Hinako Sakurai and Anna Tojo and Yukie Hayashi and {Limpias Kamiya}, {Kenji J.L.} and Tomohisa Sujino and Kaoru Takabayashi and Kenjiro Kosaki and Satowa Seki and Tadakazu Hisamatsu and Haruhiko Ogata and Takanori Kanai",

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doi = "10.2169/internalmedicine.8939-21",

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AU - Ariake, Chizuru

AU - Hosoe, Naoki

AU - Sakurai, Hinako

AU - Tojo, Anna

AU - Hayashi, Yukie

AU - Limpias Kamiya, Kenji J.L.

AU - Sujino, Tomohisa

AU - Takabayashi, Kaoru

AU - Kosaki, Kenjiro

AU - Seki, Satowa

AU - Hisamatsu, Tadakazu

AU - Ogata, Haruhiko

AU - Kanai, Takanori

PY - 2022

Y1 - 2022

N2 - Chronic enteropathy associated with solute carrier organic anion transporter family, member 2A1 (SLCO2 A1) (CEAS) is a rare autosomal recessive hereditary disease characterized by chronic persistent anemia and hypoproteinemia. Its diagnosis typically requires a genetic analysis. The efficacy of immunohistochemical staining with SLCO2A1 polyclonal antibody as a pre-diagnostic tool for CEAS has been previously reported. We herein report a patient with CEAS in whom immunohistochemical staining confirmed SLCO2A1 protein expression. The immunopositive results may have been due to nonsense-mediated RNA decay. As immunohistochemical staining of SLCO2A1 protein may show immunopositive results, a genetic analysis should also be performed when CEAS is strongly clinically suspected.

AB - Chronic enteropathy associated with solute carrier organic anion transporter family, member 2A1 (SLCO2 A1) (CEAS) is a rare autosomal recessive hereditary disease characterized by chronic persistent anemia and hypoproteinemia. Its diagnosis typically requires a genetic analysis. The efficacy of immunohistochemical staining with SLCO2A1 polyclonal antibody as a pre-diagnostic tool for CEAS has been previously reported. We herein report a patient with CEAS in whom immunohistochemical staining confirmed SLCO2A1 protein expression. The immunopositive results may have been due to nonsense-mediated RNA decay. As immunohistochemical staining of SLCO2A1 protein may show immunopositive results, a genetic analysis should also be performed when CEAS is strongly clinically suspected.

KW - balloon-assisted enteroscopy

KW - chronic enteropathy associated with SLCO2A1 gene

KW - small intestine

KW - video capsule endoscopy

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AN - SCOPUS:85137136772

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JO - Internal Medicine

JF - Internal Medicine

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ER -

Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein

Abstract

Keywords

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