Circadian phenotypes of drosophila fragile X mutants in alternative genetic backgrounds

Tatsumori Sekine, Terumi Yamaguchi, Kunikatsu Hamano, Haruhiko Siomi, Lino Saez, Norio Ishida, Masami Shimoda

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Drosophila FMR1 mutants are models of human fragile X syndrome. They show a loss of locomotor activity rhythm and severe degradation of eclosion timing. We analyzed the circadian behavior of FMR1 mutants (dfmr1BSS) in two genetic backgrounds, yellow white (yw) and Canton S (CS). The arrhythmic phenotype of circadian locomotor activity in constant darkness (DD) did not significantly change in either genetic background. Surprisingly, eclosion timing was completely restored by backcrossing dfmr1B55 with yw or CS flies. Morphological analysis of the small ventrally located lateral neurons of FMR1 mutants revealed that the dorsal-projection area was significantly larger in arrhythmic than rhythmic flies. In addition, dfmr1BSS mutants in both genetic backgrounds had a significantly lower evening peak in the light-dark (LD) cycle. These results indicate that lack of FMR1 does not affect eclosion timing, but alters locomotor activity patterns in both LD and DD conditions by affecting the arborization of small ventrally located lateral neurons. Thus, the FMR1 gene may regulate the circadian-related locomotor activity of Drosophila.

Original languageEnglish
Pages (from-to)561-571
Number of pages11
JournalZoological Science
Issue number6
Publication statusPublished - 2008 Jun 1
Externally publishedYes


  • Behavior
  • Eclosion
  • Fragile-X syndrome
  • Genetic background
  • Lateral neuron
  • Locomotor rhythm
  • Luciferase assay

ASJC Scopus subject areas

  • Animal Science and Zoology


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