TY - JOUR
T1 - Circulating microRNAs and extracellular vesicles as potential cancer biomarkers
T2 - a systematic review
AU - Matsuzaki, Juntaro
AU - Ochiya, Takahiro
N1 - Funding Information:
TO received research grant from Kewpie Corporation, Rohto Pharmaceutical Co., Ltd., Japan Atherosclerosis Research Foundation, and Inter Stem. JM has no conflict of interest.
Funding Information:
This study was supported by the ‘Development of Diagnostic Technology for Detection of miRNA in Body Fluids’ Grant from the Japan Agency for Medical Research and Development and New Energy and Industrial Technology Development Organization to TO.
Publisher Copyright:
© 2017, Japan Society of Clinical Oncology.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs. In addition, similar diagnostic accuracies were reported using long non-coding RNAs or proteins present in extracellular vesicles, although these evidences were based on a limited number of studies.
AB - Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs. In addition, similar diagnostic accuracies were reported using long non-coding RNAs or proteins present in extracellular vesicles, although these evidences were based on a limited number of studies.
KW - Cancer
KW - Extracellular vesicle
KW - Liquid biopsy
KW - Long non-coding RNA
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=85014045671&partnerID=8YFLogxK
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U2 - 10.1007/s10147-017-1104-3
DO - 10.1007/s10147-017-1104-3
M3 - Review article
C2 - 28243946
AN - SCOPUS:85014045671
SN - 1341-9625
VL - 22
SP - 413
EP - 420
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 3
ER -
