TY - JOUR
T1 - Clear cell variant of malignant melanoma of the uterine cervix
T2 - A case report and review of the literature
AU - Furuya, Mitsuko
AU - Shimizu, Michio
AU - Nishihara, Hiroshi
AU - Ito, Tomoo
AU - Sakuragi, Noriaki
AU - Ishikura, Hiroshi
AU - Yoshiki, Takashi
PY - 2001
Y1 - 2001
N2 - Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.
AB - Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.
KW - Clear cell
KW - Malignant melanoma
KW - Uterine cervix
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U2 - 10.1006/gyno.2000.6091
DO - 10.1006/gyno.2000.6091
M3 - Article
C2 - 11263942
AN - SCOPUS:0035097056
SN - 0090-8258
VL - 80
SP - 409
EP - 412
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -