Clear cell variant of malignant melanoma of the uterine cervix: A case report and review of the literature

Mitsuko Furuya, Michio Shimizu, Hiroshi Nishihara, Tomoo Ito, Noriaki Sakuragi, Hiroshi Ishikura, Takashi Yoshiki

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalGynecologic Oncology
Issue number3
Publication statusPublished - 2001
Externally publishedYes


  • Clear cell
  • Malignant melanoma
  • Uterine cervix

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology


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