Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode

Satoshi Nishino; Mami Kunita; Yoshiyuki Kani; Shigeru Ohba; Hideaki Matsushima; Tadashi Tokii; Yuzo Nishida

doi:10.1016/S1387-7003(00)00023-X

Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η¹-coordination mode

Satoshi Nishino, Mami Kunita, Yoshiyuki Kani, Shigeru Ohba, Hideaki Matsushima, Tadashi Tokii, Yuzo Nishida

Department of Humanities and Social Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We have obtained clear evidence that a copper(II)-peroxide adduct with an η¹-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Inorganic Chemistry Communications
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/S1387-7003(00)00023-X
Publication status	Published - 2000 Oct 7

Keywords

Cleavage of protein
Copper(II)-peroxide adduct
Model reaction for PAM enzyme
η-Coordination mode

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/S1387-7003(00)00023-X

Cite this

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abstract = "We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.",

keywords = "Cleavage of protein, Copper(II)-peroxide adduct, Model reaction for PAM enzyme, η-Coordination mode",

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T1 - Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode

AU - Nishino, Satoshi

AU - Kunita, Mami

AU - Kani, Yoshiyuki

AU - Ohba, Shigeru

AU - Matsushima, Hideaki

AU - Tokii, Tadashi

AU - Nishida, Yuzo

PY - 2000/10/7

Y1 - 2000/10/7

N2 - We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

AB - We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

KW - Cleavage of protein

KW - Copper(II)-peroxide adduct

KW - Model reaction for PAM enzyme

KW - η-Coordination mode

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