Click reaction based on the biosynthesis of firefly luciferin

Tomohisa Toyama, Tsuyoshi Saitoh, Yuka Takahashi, Kotaro Oka, Daniel Citterio, Koji Suzuki, Shigeru Nishiyama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Novel click chemistry was developed based on the biosynthetic process of firefly luciferin, which includes an ideal coupling of a cyanothiazole residue with cysteine. Among various biomimetic couplings of nitriles with cysteine derivatives, the approach using 4-cyanopyridine and cysteine methyl ester provided a very rapid and quantitative conversion to the corresponding thiazole without any metal catalyst at room temperature.

Original languageEnglish
Pages (from-to)753-755
Number of pages3
JournalChemistry Letters
Issue number5
Publication statusPublished - 2017


  • Biomimetic coupling
  • Click chemistry
  • Firefly luciferin

ASJC Scopus subject areas

  • General Chemistry


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