Clinical characteristics of pediatric febrile urinary tract infection in Japan

Takuma Ohnishi, Yoshinori Mishima, Nozomi Matsuda, Daisuke Sato, Daisuke Umino, Ryuta Yonezawa, Keiji Kinoshita, Kikuko Tamura, Shigenao Mimura, Shohei Ariji, Naonori Maeda, Keiko Ozaki, Hiroyuki Fukushima, Tomohiro Arakuma, Satoko Tsuchida, Hajime Nishimoto, Yoshinori Araki, Makoto Yoshida, Takuya Tamame, Shigeru SuzukiToshio Sekijima, Takanori Kowase, Kanae Takahashi, Isamu Kamimaki

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: Febrile urinary tract infection (fUTI) is the most common serious bacterial infection in children. Despite this, there have been no studies examining the clinical features of pediatric fUTI in Japan. The purpose of this study was to describe the clinical characteristics of fUTI in Japanese children. Methods: A multicenter, retrospective, observational study was conducted at 21 hospitals in Japan. Children under the age of 15 years who were diagnosed with fUTI between 2008 and 2017 were included. The diagnostic criteria were a temperature over 38 °C and the presence of a single bacterial pathogen in urine culture. Patient characteristics were obtained from medical records. Results: In total, 2,049 children were included in the study. The median age was 5 months, and 59.3% were male. It was found that 87.0% of the males and 53.2% of the females were under 1 year of age. The main causative pathogens identified were Escherichia coli and Enterococcus spp., accounting for 76.6% and 9.8% of infections, respectively. Conclusions: There was a male predominance of fUTI in Japanese children, particularly in infants. Enterococcus spp. were the second most frequent causative pathogen; therefore, Gram staining of urine samples is strongly recommended before initiating antibiotic therapy.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalInternational Journal of Infectious Diseases
Publication statusPublished - 2021 Mar


  • Enterococcus
  • Hydronephrosis
  • Urinary tract infection
  • Vesicoureteral reflux

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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