TY - JOUR
T1 - Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients
AU - Yagi, Kazuma
AU - Morimoto, Kozo
AU - Ishii, Makoto
AU - Namkoong, Ho
AU - Okamori, Satoshi
AU - Asakura, Takanori
AU - Suzuki, Shoji
AU - Asami, Takahiro
AU - Uwamino, Yoshifumi
AU - Funatsu, Yohei
AU - Fujiwara, Hiroshi
AU - Kamata, Hirofumi
AU - Nishimura, Tomoyasu
AU - Betsuyaku, Tomoko
AU - Kurashima, Atsuyuki
AU - Hasegawa, Naoki
N1 - Publisher Copyright:
© 2017 The Author(s)
PY - 2018/2
Y1 - 2018/2
N2 - Background Mycobacterium lentiflavum is a slow-growing non-tuberculous Mycobacterium that is often associated with an immunocompromised state and cervical lymphadenitis in young children. However, little is known about the clinical importance of pulmonary infection with M. lentiflavum in adults. Methods The medical records of all adults who met the diagnostic criteria of pulmonary M. lentiflavum disease at Keio University Hospital and Fukujuji Hospital from 2001 to 2015 were reviewed. In addition, the PubMed database was searched to identify further reported cases in non-HIV adults. Results Five cases of pulmonary M. lentiflavum disease were identified in the medical records search and 11 additional cases were identified in the literature review. Eleven of the total 16 cases were female, and 15 of 16 cases showed a nodular/bronchiectatic pattern on chest computed tomography imaging. No cases showed an aggressive clinical course of pulmonary M. lentiflavum disease, although one patient died of an exacerbation of underlying vasculitis and bacterial pneumonia. Conclusions The clinical characteristics of pulmonary M. lentiflavum disease in adult patients were identified. This disease mainly affects females, displays a nodular/bronchiectatic pattern on chest computed tomography imaging, and does not demonstrate an aggressive clinical course. Further larger studies are needed to reveal detailed clinical features.
AB - Background Mycobacterium lentiflavum is a slow-growing non-tuberculous Mycobacterium that is often associated with an immunocompromised state and cervical lymphadenitis in young children. However, little is known about the clinical importance of pulmonary infection with M. lentiflavum in adults. Methods The medical records of all adults who met the diagnostic criteria of pulmonary M. lentiflavum disease at Keio University Hospital and Fukujuji Hospital from 2001 to 2015 were reviewed. In addition, the PubMed database was searched to identify further reported cases in non-HIV adults. Results Five cases of pulmonary M. lentiflavum disease were identified in the medical records search and 11 additional cases were identified in the literature review. Eleven of the total 16 cases were female, and 15 of 16 cases showed a nodular/bronchiectatic pattern on chest computed tomography imaging. No cases showed an aggressive clinical course of pulmonary M. lentiflavum disease, although one patient died of an exacerbation of underlying vasculitis and bacterial pneumonia. Conclusions The clinical characteristics of pulmonary M. lentiflavum disease in adult patients were identified. This disease mainly affects females, displays a nodular/bronchiectatic pattern on chest computed tomography imaging, and does not demonstrate an aggressive clinical course. Further larger studies are needed to reveal detailed clinical features.
KW - Case series
KW - Literature review
KW - Non-tuberculous mycobacteria
KW - Pulmonary Mycobacterium lentiflavum disease
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U2 - 10.1016/j.ijid.2017.12.001
DO - 10.1016/j.ijid.2017.12.001
M3 - Article
C2 - 29225071
AN - SCOPUS:85039704732
SN - 1201-9712
VL - 67
SP - 65
EP - 69
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
