Clinical determinants of life satisfaction in chronic schizophrenia: Data from the CATIE study

Gagan Fervaha, Ofer Agid, Hiroyoshi Takeuchi, George Foussias, Gary Remington

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Objective: Quality of life is seen as an important outcome variable for patients with schizophrenia. However, the precise definition of this construct varies and has often been used to define health-related domains. The present study sought to focus on global life satisfaction as a key subjective domain and determine its relationship with clinical variables. Method: The study sample included 1437 patients with chronic schizophrenia who participated in the Clinical Antipsychotic Trial of Intervention Effectiveness (CATIE) study. Patients were evaluated with a comprehensive battery of assessments capturing symptoms, cognition and medication side effects, among other variables. Life satisfaction was evaluated with a global self-report item. Results: Greater depressive symptoms were the most robust indicator of worse life satisfaction. Lower life satisfaction was also associated with poorer psychosocial functioning, greater symptoms of anxiety, apathy and more negative attitudes toward medication. Taken together, these variables explained 20% of the variance in life satisfaction scores. Positive symptoms and other medication side effects also negatively influenced life satisfaction scores. Conclusions: These results affirm that clinical variables have an adverse effect on the overall subjective well-being of patients with schizophrenia. The relatively small amount of variance explained, though, argues for a better understanding of those other variables that contribute to life satisfaction.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalSchizophrenia Research
Issue number1-3
Publication statusPublished - 2013 Dec
Externally publishedYes


  • Life satisfaction
  • Quality of life
  • Schizophrenia
  • Symptoms
  • Well-being

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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