Clinical evaluation of celiprolol hydrochloride (Selectol®) to the hypertensive patients with type 2 diabetes - Combination therapy with Ca²⁺antagonist and/or ACE inhibitor

The aim of this study was to confirm the clinical efficacy, metabolic effects and safety of celiprolol, a selective β₁-blocker with β₂ agonist property, to essential hypertensive patients with diabetes aged 53 to 92 years (mean, 70 years), recognized insufficient antihypertensive effects by Ca²⁺antagonist and/or ACE inhibitor. Fifteen patients were administered celiprolol at daily dose of 100∼200 mg during six months. The obtained results were followed. Blood pressure decreased significantly from 164.8 ± 5.8/92.8 ± 3.0 mmHg to 151.7 ± 3.8/84.7 ± 3.6 mmHg after six months of treatment, respectively (p<0.05). On the oral glucose tolerance test, celiplorol had no influence to values of blood sugar and blood insulin. As well as HbA_1c and Body mass index, no significant changes were observed. Total cholesterol and triglyceride decreased significantly from 218.9 ± 10.4 mg/dL and 125.3 ± 12.9 mg/dL to 193.8 ± 10.4 mg/dL and 88.6 ± 4.1 mg/dL, respectively (p<0.05). HDL cholesterol increased from 52.9 ± 3.8 mg/dL at the before treatment to 54.4 ± 6.9 mg/dL at the six months after treatment, but not significant. No side effcts were noted in all patients. The above results indicated that celiprolol is useful β-blocker to essential hypertensive patients with type 2 diabetes.