Clinical experience of cardiovascular surgery using GRF (gelatin-resorcin-formalin) biological glue

H. Shimizu, T. Ueda, R. Yozu, I. Kiso, K. Nishikawa, T. Maehara, M. Okura, H. Kaneko, H. Imamura, S. Kawada

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1 Citation (Scopus)


Bachet and co-workers introduced GRF glue into the surgery of acute aortic dissection and reported excellent results. However this product had not been available until recently in Japan, at which time we had the opportunity to evaluate the usefulness of this material in cardiovascular surgery. From October 1992 to April 1993, GRF glue was applied to 20 patients, including seven patients with acute and five patients with chronic aortic dissection, two patients with thoracic and one patient with abdominal aortic aneurysm, four patients with aortic valvular disease, and one patient with ventricular septal perforation due to acute myocardial infarction. We lost five patients early postoperatively mainly due to the poor preoperative condition of these patients. Especially in patients with acute aortic dissection, the GRF glue proved to be very useful as an adhesive. The adhered sites were firmly reinforced and exhibited appropriate elasticity to suture. In other cases, the GRF glue was mainly used as a hemostatic agent, that is, it was applied over the incised tissue. It was efficient even in the application to the left ventricle when ventricular septal perforation occurred due to acute AMI or the severely calcificated aorta of Takayasu aortitis, both of which have been said to be difficult to suture and to arrest the bleeding. As the GRF glue was ineffective only in one case in whom it was applied to the active bleeding coronary sinus site, we believe that it should be used after drying the application site as much as possible. No side effects arose in any case. We conclude that GRF glue is safe and easy to use and is a very useful material for application to cardiovascular operation.

Original languageEnglish
Pages (from-to)675-678
Number of pages4
JournalJapanese Journal of Artificial Organs
Issue number3
Publication statusPublished - 1994


  • GRF, gelatin-resorcin-formalin
  • biological glue
  • cardiovascular surgery

ASJC Scopus subject areas

  • Biophysics


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