TY - JOUR
T1 - Clinical Factors for Rapid Endothelial Cell Loss After Corneal Transplantation
T2 - Novel Findings From the Aqueous Humor
AU - Yazu, Hiroyuki
AU - Yamaguchi, Takefumi
AU - Tsubota, Kazuo
AU - Shimazaki, Jun
N1 - Funding Information:
Part of this work was supported by a Grant-in-Aid for Scientific Research (15K10906, 20383771) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology and a Grant from Uehara Scientific Foundation (TY, Tokyo Japan).
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Purpose of Review: To review the clinical factors for endothelial cell density (ECD) loss and graft failure after corneal transplantation. Recent Findings: Reduction of ECD after corneal transplantation is associated with various clinical factors, such as the presence of glaucoma, graft diameter, donor age, donor diabetes, and donor gender. Recently, we reported the severe preexisting iris damage was one of the clinical factors for rapid ECD loss and graft failure. We also showed that preexisting iris damage causes chronic elevation of cytokine levels in the aqueous humor (AqH). Furthermore, the higher preoperative levels of specific cytokines in the AqH were associated with a rapid reduction in ECD after penetrating keratoplasty and endothelial keratoplasty. Summary: Iris damage and preoperative cytokine levels in the AqH can be potential biomarkers for the reduction of ECD after corneal transplantation, although we need to substantiate the exact mechanism of the endothelial cell loss.
AB - Purpose of Review: To review the clinical factors for endothelial cell density (ECD) loss and graft failure after corneal transplantation. Recent Findings: Reduction of ECD after corneal transplantation is associated with various clinical factors, such as the presence of glaucoma, graft diameter, donor age, donor diabetes, and donor gender. Recently, we reported the severe preexisting iris damage was one of the clinical factors for rapid ECD loss and graft failure. We also showed that preexisting iris damage causes chronic elevation of cytokine levels in the aqueous humor (AqH). Furthermore, the higher preoperative levels of specific cytokines in the AqH were associated with a rapid reduction in ECD after penetrating keratoplasty and endothelial keratoplasty. Summary: Iris damage and preoperative cytokine levels in the AqH can be potential biomarkers for the reduction of ECD after corneal transplantation, although we need to substantiate the exact mechanism of the endothelial cell loss.
KW - Aqueous humor
KW - Corneal endothelial cell
KW - Corneal transplantation
KW - Cytokine
KW - Iris damage
UR - http://www.scopus.com/inward/record.url?scp=85081086044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85081086044&partnerID=8YFLogxK
U2 - 10.1007/s40135-019-00204-1
DO - 10.1007/s40135-019-00204-1
M3 - Review article
AN - SCOPUS:85081086044
SN - 2167-4868
VL - 7
SP - 89
EP - 97
JO - Current Ophthalmology Reports
JF - Current Ophthalmology Reports
IS - 2
ER -
