Clinical features of mycoplasma pneumoniae infections in the 2010 epidemic season: Report of two cases with unusual presentations

Tomoaki Takei; Miyuki Morozumi; Hirohiko Ozaki; Hisayo Fujita; Kimiko Ubukata; Isshi Kobayashi; Keisuke Kadota; Takako Miyamae; Shumpei Yokota; Satoshi Iwata; Takashi Takahashi

doi:10.1016/j.pedneo.2012.11.016

Clinical features of mycoplasma pneumoniae infections in the 2010 epidemic season: Report of two cases with unusual presentations

Tomoaki Takei, Miyuki Morozumi, Hirohiko Ozaki, Hisayo Fujita, Kimiko Ubukata, Isshi Kobayashi, Keisuke Kadota, Takako Miyamae, Shumpei Yokota, Satoshi Iwata, Takashi Takahashi

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Mycoplasma pneumoniae (Mp) is one of the main pathogens causing community-acquired pneumonia, particularly in young individuals. Host immune response appears to play an important role in prolonged symptoms, as well as in the recent increasing prevalence of drug-resistant Mp isolated from patients. Case 1 had a prolonged clinical course caused by drug-resistant Mp and received steroid therapy despite Mp susceptibility to some antimicrobial agents. Serum cytokine profiles revealed elevation of interleukin-6/-10 and interferon-γ in acute phase. Case 2 had mycoplasmal myocarditis without any respiratory symptoms, which resolved spontaneously without the administration of any antimicrobial agent. These observations suggest that host immune response probably contributes to the etiology of Mp-associated complications.

Original language	English
Pages (from-to)	402-405
Number of pages	4
Journal	Pediatrics and Neonatology
Volume	54
Issue number	6
DOIs	https://doi.org/10.1016/j.pedneo.2012.11.016
Publication status	Published - 2013 Dec
Externally published	Yes

Keywords

Mycoplasma pneumoniae
cytokine
drug resistance
myocarditis
steroid

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.pedneo.2012.11.016

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title = "Clinical features of mycoplasma pneumoniae infections in the 2010 epidemic season: Report of two cases with unusual presentations",

abstract = "Mycoplasma pneumoniae (Mp) is one of the main pathogens causing community-acquired pneumonia, particularly in young individuals. Host immune response appears to play an important role in prolonged symptoms, as well as in the recent increasing prevalence of drug-resistant Mp isolated from patients. Case 1 had a prolonged clinical course caused by drug-resistant Mp and received steroid therapy despite Mp susceptibility to some antimicrobial agents. Serum cytokine profiles revealed elevation of interleukin-6/-10 and interferon-γ in acute phase. Case 2 had mycoplasmal myocarditis without any respiratory symptoms, which resolved spontaneously without the administration of any antimicrobial agent. These observations suggest that host immune response probably contributes to the etiology of Mp-associated complications.",

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author = "Tomoaki Takei and Miyuki Morozumi and Hirohiko Ozaki and Hisayo Fujita and Kimiko Ubukata and Isshi Kobayashi and Keisuke Kadota and Takako Miyamae and Shumpei Yokota and Satoshi Iwata and Takashi Takahashi",

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doi = "10.1016/j.pedneo.2012.11.016",

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AU - Takei, Tomoaki

AU - Morozumi, Miyuki

AU - Ozaki, Hirohiko

AU - Fujita, Hisayo

AU - Ubukata, Kimiko

AU - Kobayashi, Isshi

AU - Kadota, Keisuke

AU - Miyamae, Takako

AU - Yokota, Shumpei

AU - Iwata, Satoshi

AU - Takahashi, Takashi

PY - 2013/12

Y1 - 2013/12

N2 - Mycoplasma pneumoniae (Mp) is one of the main pathogens causing community-acquired pneumonia, particularly in young individuals. Host immune response appears to play an important role in prolonged symptoms, as well as in the recent increasing prevalence of drug-resistant Mp isolated from patients. Case 1 had a prolonged clinical course caused by drug-resistant Mp and received steroid therapy despite Mp susceptibility to some antimicrobial agents. Serum cytokine profiles revealed elevation of interleukin-6/-10 and interferon-γ in acute phase. Case 2 had mycoplasmal myocarditis without any respiratory symptoms, which resolved spontaneously without the administration of any antimicrobial agent. These observations suggest that host immune response probably contributes to the etiology of Mp-associated complications.

AB - Mycoplasma pneumoniae (Mp) is one of the main pathogens causing community-acquired pneumonia, particularly in young individuals. Host immune response appears to play an important role in prolonged symptoms, as well as in the recent increasing prevalence of drug-resistant Mp isolated from patients. Case 1 had a prolonged clinical course caused by drug-resistant Mp and received steroid therapy despite Mp susceptibility to some antimicrobial agents. Serum cytokine profiles revealed elevation of interleukin-6/-10 and interferon-γ in acute phase. Case 2 had mycoplasmal myocarditis without any respiratory symptoms, which resolved spontaneously without the administration of any antimicrobial agent. These observations suggest that host immune response probably contributes to the etiology of Mp-associated complications.

KW - Mycoplasma pneumoniae

KW - cytokine

KW - drug resistance

KW - myocarditis

KW - steroid

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Clinical features of mycoplasma pneumoniae infections in the 2010 epidemic season: Report of two cases with unusual presentations

Abstract

Keywords

ASJC Scopus subject areas

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