TY - JOUR
T1 - Clinical implications of noncoding indels in the surfactant‐encoding genes in lung cancer
AU - Nakagomi, Takahiro
AU - Hirotsu, Yosuke
AU - Goto, Taichiro
AU - Shikata, Daichi
AU - Yokoyama, Yujiro
AU - Higuchi, Rumi
AU - Otake, Sotaro
AU - Amemiya, Kenji
AU - Oyama, Toshio
AU - Mochizuki, Hitoshi
AU - Omata, Masao
N1 - Funding Information:
Funding: This study was supported by a Grant‐in‐Aid for Genome Research Project from Yamanashi Prefecture (to Y.H. and M.O.) and by grants from Japanese Foundation for Multidisciplinary Treatment of Cancer (to T.G.).
Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/4
Y1 - 2019/4
N2 - Lung cancer arises from the accumulation of genetic mutations, usually in exons. A recent study identified indel mutations in the noncoding region of surfactant‐encoding genes in lung adenocarcinoma cases. In this study, we recruited 94 patients with 113 lung cancers (88 adenocarcinomas, 16 squamous cell carcinomas, and nine other histologies) who had undergone surgery in our department. A cancer panel was designed in‐house for analyzing the noncoding regions, and targeted sequencing was performed. Indels in the noncoding region of surfactantencoding genes were identified in 29/113 (25.7%) cases and represent the precise cell of origin for the lung cancer, irrespective of histological type and/or disease stage. In clinical practice, these indels may be used as clonal markers in patients with multiple cancers and to determine the origin of cancer of unknown primary site.
AB - Lung cancer arises from the accumulation of genetic mutations, usually in exons. A recent study identified indel mutations in the noncoding region of surfactant‐encoding genes in lung adenocarcinoma cases. In this study, we recruited 94 patients with 113 lung cancers (88 adenocarcinomas, 16 squamous cell carcinomas, and nine other histologies) who had undergone surgery in our department. A cancer panel was designed in‐house for analyzing the noncoding regions, and targeted sequencing was performed. Indels in the noncoding region of surfactantencoding genes were identified in 29/113 (25.7%) cases and represent the precise cell of origin for the lung cancer, irrespective of histological type and/or disease stage. In clinical practice, these indels may be used as clonal markers in patients with multiple cancers and to determine the origin of cancer of unknown primary site.
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U2 - 10.3390/cancers11040552
DO - 10.3390/cancers11040552
M3 - Article
AN - SCOPUS:85065450050
SN - 2072-6694
VL - 11
JO - Cancers
JF - Cancers
IS - 4
M1 - 552
ER -
