Clinical outcome in patients with small intestinal non-Hodgkin lymphoma

Shinichi Kako, Kumi Oshima, Miki Sato, Kiriko Terasako, Shinya Okuda, Hideki Nakasone, Rie Yamazaki, Yukie Tanaka, Aki Tanihara, Yutaka Kawamura, Hirokazu Kiyosaki, Takakazu Higuchi, Junji Nishida, Fumio Konishi, Yoshinobu Kanda

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


The clinical features and outcome of small intestinal lymphoma remain unclear. We retrospectively analyzed 23 patients who had non-Hodgkin lymphoma with a small intestinal lesion. With a median follow-up of 37 months, the 5-year overall survival and failure-free survival (FFS) were 64% and 60%, respectively. In a univariate analysis, a worse performance status at the start of treatment and the occurrence of abdominal symptoms or perforation during treatment were associated with poor survival. Perforation often resulted in a dismal prognosis in patients with uncontrollable lymphoma, but not in patients with lymphoma in remission. The role of surgery in small intestinal lymphoma remains equivocal. In the current study, surgery before other therapies favorably influenced FFS, and all patients who underwent complete resection of the small intestinal lesion had extremely favorable results. Further studies are warranted to establish optimal therapeutic strategies.

Original languageEnglish
Pages (from-to)1618-1624
Number of pages7
JournalLeukemia and Lymphoma
Issue number10
Publication statusPublished - 2009
Externally publishedYes


  • Abdominal symptoms
  • Perforation
  • Small intestinal lymphoma
  • Surgical procedure

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


Dive into the research topics of 'Clinical outcome in patients with small intestinal non-Hodgkin lymphoma'. Together they form a unique fingerprint.

Cite this