Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis

Fumie Shimada, Yusuke Yoshimatsu, Tomohisa Sujino, Tomohiro Fukuda, Yasuhiro Aoki, Yukie Hayashi, Anna Tojo, Takaaki Kawaguchi, Hiroki Kiyohara, Shinya Sugimoto, Kosaku Nanki, Yohei Mikami, Kentaro Miyamoto, Kaoru Takabayashi, Naoki Hosoe, Motohiko Kato, Haruhiko Ogata, Makoto Naganuma, Takanori Kanai

Research output: Contribution to journalArticlepeer-review

Abstract

Indigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as pulmonary hypertension. The natural history of patients with ulcerative colitis who discontinued indigo naturalis after induction therapy is unknown. Moreover, the clinical features of patients who relapsed within 52 weeks after the discontinuation of indigo naturalis are unclear. This study aimed to assess the clinical outcomes of patients with ulcerative colitis after discontinuation of indigo naturalis and to identify potential markers responsible for relapse. This single-center retrospective study investigated the follow-up of 72 patients who achieved a clinical response 8 weeks after indigo naturalis treatment. We observed relapse in patients with ulcerative colitis after the discontinuation of indigo naturalis. We analyzed the factors predicting long-term outcomes after discontinuation of indigo naturalis. Relapse was observed in 24%, 57%, and 71% of patients at 8, 26, and 52 weeks, respectively. There were no predictive markers in patients who relapsed within 52 weeks after the discontinuation of indigo naturalis. The ulcerative colitis relapse rate after indigo naturalis discontinuation was high. Follow-up treatment is required after the discontinuation of indigo naturalis in patients with ulcerative colitis.

Original languageEnglish
Article number5778
JournalScientific reports
Volume14
Issue number1
DOIs
Publication statusPublished - 2024 Dec

Keywords

  • Discontinuation
  • Indigo naturalis
  • Relapse
  • Ulcerative colitis

ASJC Scopus subject areas

  • General

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