Clinical Practice Guidelines for the Management of Congenital Syphilis in Japan, 2023: Executive Summary

Yoshinori Ito; Takuya Yamagishi; Chiaki Ikenoue; Naruhiko Ishiwada; Kenta Ito; Sota Iwatani; Kazunobu Ouchi; Kei Kawana; Hiroyuki Shimizu; Masayoshi Shinjoh; Noriko Takeuchi; Takeshi Tsugawa; Takanori Funaki; Munehiro Furuichi; Tadashi Hoshino; Hiroshige Mikamo; Isao Miyairi; Hiroyuki Moriuchi; Ichiro Morioka; Yuka Yamagishi; Masaaki Mori

doi:10.1097/INF.0000000000004665

Clinical Practice Guidelines for the Management of Congenital Syphilis in Japan, 2023: Executive Summary

Yoshinori Ito, Takuya Yamagishi, Chiaki Ikenoue, Naruhiko Ishiwada, Kenta Ito, Sota Iwatani, Kazunobu Ouchi, Kei Kawana, Hiroyuki Shimizu, Masayoshi Shinjoh, Noriko Takeuchi, Takeshi Tsugawa, Takanori Funaki, Munehiro Furuichi, Tadashi Hoshino, Hiroshige Mikamo, Isao Miyairi, Hiroyuki Moriuchi, Ichiro Morioka, Yuka YamagishiMasaaki Mori

Research output: Contribution to journal › Review article › peer-review

Abstract

Congenital syphilis (CS) is a mother-to-child infection caused by the bacterium Treponema pallidum, transmitted through the placenta. In Japan, the number of syphilis cases has recently increased, accompanied by an increase in CS cases. Thus, automated methods for serum antibodies with serial values, without a 2× dilution sequence, have been widely used. Moreover, benzathine penicillin G was introduced in Japan in 2021. In response to the recent surge in CS, the first edition of the clinical practice guidelines for the management of CS was developed by a committee comprising representatives from 4 Japanese medical societies. This summary outlines 5 clinical questions with statements and expert comments regarding diagnosis, treatment and follow-up requirements. These guidelines aim to assist in the management of patients with CS infection.

Original language	English
Pages (from-to)	e90-e94
Journal	Pediatric Infectious Disease Journal
Volume	44
Issue number	3
DOIs	https://doi.org/10.1097/INF.0000000000004665
Publication status	Published - 2025 Mar 1
Externally published	Yes

Keywords

Japan
congenital syphilis
guideline
syphilis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000004665

Cite this

Ito, Y., Yamagishi, T., Ikenoue, C., Ishiwada, N., Ito, K., Iwatani, S., Ouchi, K., Kawana, K., Shimizu, H., Shinjoh, M., Takeuchi, N., Tsugawa, T., Funaki, T., Furuichi, M., Hoshino, T., Mikamo, H., Miyairi, I., Moriuchi, H., Morioka, I., ... Mori, M. (2025). Clinical Practice Guidelines for the Management of Congenital Syphilis in Japan, 2023: Executive Summary. Pediatric Infectious Disease Journal, 44(3), e90-e94. https://doi.org/10.1097/INF.0000000000004665

Ito, Y, Yamagishi, T, Ikenoue, C, Ishiwada, N, Ito, K, Iwatani, S, Ouchi, K, Kawana, K, Shimizu, H, Shinjoh, M, Takeuchi, N, Tsugawa, T, Funaki, T, Furuichi, M, Hoshino, T, Mikamo, H, Miyairi, I, Moriuchi, H, Morioka, I, Yamagishi, Y & Mori, M 2025, 'Clinical Practice Guidelines for the Management of Congenital Syphilis in Japan, 2023: Executive Summary', Pediatric Infectious Disease Journal, vol. 44, no. 3, pp. e90-e94. https://doi.org/10.1097/INF.0000000000004665

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abstract = "Congenital syphilis (CS) is a mother-to-child infection caused by the bacterium Treponema pallidum, transmitted through the placenta. In Japan, the number of syphilis cases has recently increased, accompanied by an increase in CS cases. Thus, automated methods for serum antibodies with serial values, without a 2× dilution sequence, have been widely used. Moreover, benzathine penicillin G was introduced in Japan in 2021. In response to the recent surge in CS, the first edition of the clinical practice guidelines for the management of CS was developed by a committee comprising representatives from 4 Japanese medical societies. This summary outlines 5 clinical questions with statements and expert comments regarding diagnosis, treatment and follow-up requirements. These guidelines aim to assist in the management of patients with CS infection.",

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T1 - Clinical Practice Guidelines for the Management of Congenital Syphilis in Japan, 2023

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AU - Ito, Yoshinori

AU - Yamagishi, Takuya

AU - Ikenoue, Chiaki

AU - Ishiwada, Naruhiko

AU - Ito, Kenta

AU - Iwatani, Sota

AU - Ouchi, Kazunobu

AU - Kawana, Kei

AU - Shimizu, Hiroyuki

AU - Shinjoh, Masayoshi

AU - Takeuchi, Noriko

AU - Tsugawa, Takeshi

AU - Funaki, Takanori

AU - Furuichi, Munehiro

AU - Hoshino, Tadashi

AU - Mikamo, Hiroshige

AU - Miyairi, Isao

AU - Moriuchi, Hiroyuki

AU - Morioka, Ichiro

AU - Yamagishi, Yuka

AU - Mori, Masaaki

PY - 2025/3/1

Y1 - 2025/3/1

N2 - Congenital syphilis (CS) is a mother-to-child infection caused by the bacterium Treponema pallidum, transmitted through the placenta. In Japan, the number of syphilis cases has recently increased, accompanied by an increase in CS cases. Thus, automated methods for serum antibodies with serial values, without a 2× dilution sequence, have been widely used. Moreover, benzathine penicillin G was introduced in Japan in 2021. In response to the recent surge in CS, the first edition of the clinical practice guidelines for the management of CS was developed by a committee comprising representatives from 4 Japanese medical societies. This summary outlines 5 clinical questions with statements and expert comments regarding diagnosis, treatment and follow-up requirements. These guidelines aim to assist in the management of patients with CS infection.

AB - Congenital syphilis (CS) is a mother-to-child infection caused by the bacterium Treponema pallidum, transmitted through the placenta. In Japan, the number of syphilis cases has recently increased, accompanied by an increase in CS cases. Thus, automated methods for serum antibodies with serial values, without a 2× dilution sequence, have been widely used. Moreover, benzathine penicillin G was introduced in Japan in 2021. In response to the recent surge in CS, the first edition of the clinical practice guidelines for the management of CS was developed by a committee comprising representatives from 4 Japanese medical societies. This summary outlines 5 clinical questions with statements and expert comments regarding diagnosis, treatment and follow-up requirements. These guidelines aim to assist in the management of patients with CS infection.

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KW - guideline

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Clinical Practice Guidelines for the Management of Congenital Syphilis in Japan, 2023: Executive Summary

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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