Clinical Role of Vascular Endothelial Growth Factor (VEGF) and Hepatocyte Growth Factor (HGF) in Type-2 Diabetic Patients

Michiyo Takayama, Ken Shinmura, Hiroshi Hasegawa, Masato Tani, Toshiko Wakabayashi, Kei Shinoda, Susumu Ishida, Masakazu Yamada

Research output: Contribution to journalArticlepeer-review


We performed two studies to investigate the clinical roles of VEGF and HGF in diabetes mellitus. (1) Serum concentrations of VEGF and HGF were measured in type-2 diabetic patients (DM, n = 74) and control subjects (C, n = 44) by enzyme-linked immunosorbent assay, and their relationship to fasting plasma glucose (FPG), hemoglobin Aic, total cholesterol, high-density lipoprotein cholesterol (HDL-C), liver function, systolic blood pressure, smoking, and diabetic angiopathy were analyzed. (2) VEGF and HGF concentrations were measured in both the serum and anterior aqueous humor of type-2 diabetic patients (n = 33) and non-diabetic patients (n = 12) who underwent eye surgery, and their correlations with diabetic retinopathy were determined. (1) There were no differences in serum VEGF between C and DM, but, serum VEGF was significantly higher in DM with diabetic angiopathy. Serum HGF was higher in DM and smokers, and inversely correlated with HDL-C and FPG. (2) Neither serum VEGF nor HGF were associated with retinopathy, but anterior aqueous humor VEGF was extremely higher and HGF tended to be higher in DM with preproliferative diabetic retinopathy. VEGF and HGF were not correlated in serum, but a positive correlation was observed in anterior aqueous humor. These results suggest that VEGF and HGF affect diabetic retinopathy, however, no relationship to diabetic macroangiopathy could be detected.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalJournal of the Japan Diabetes Society
Issue number5
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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