Clinical study of calcium polycarbophil fine granule on irritable bowel syndrome

Tomonori Wada, Yuji Yoshikawa, Naohisa Yahagi, Norio Kawamura, Nobuyuki Kakei, Yasuo Matsubara, Masahiro Tsuji, Kazumasa Miki

Research output: Contribution to journalArticlepeer-review


The efficacy, safety and usefulness of calcium polycarbophil fine granule (HSR237 G : 3.0g/day) on irritable bowel syndrome (IBS) were investigated by open study. The number of cases in total was 26, that of the final global improvement rating was 22, the overall safety rating was 25 and the global utility rating was 22. In the global improvement ratings on gastrointestinal symptoms and stool disorders, the rates of cases assessed as moderately improved or more were 59.1% (13/22) and 68.2%(15/22), respectively. The rates in the final global improvement was 68.2%(15/22). The rates in the diarrhea and constipation predominant cases were 66.7%(12/18) and 75.0%(3/4), respectively. The adverse reactions was not found. The rate of abnormal changes in clinical laboratory findings was 4.0%(I/ 25), which was slightly and not serious. The rate of the cases assessed asno problem in safety in the overall safety rating was 96.0% (24/25). In the global utility rating, the rate of cases assessed as useful or more was 63.6% (14/22). From above results, it was considered that calcium polycarbophil fine granule is very useful in the treatment of irritable bowel syndrome.

Original languageEnglish
Pages (from-to)231-232
Number of pages2
JournalFortschritte der Medizin
Issue number32
Publication statusPublished - 1998 Nov 20
Externally publishedYes


  • Calcium polycarbophil
  • Constipation
  • Diarrhea
  • Fine granule
  • Gastrointestinal symptoms
  • Irritable bowel syndrome
  • Stool disorders

ASJC Scopus subject areas

  • Medicine(all)


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