Clinicopathologic assessment of prenatally diagnosed lung diseases

Tatsuo Kuroda, Nobuyuki Morikawa, Yoshihiro Kitano, Haruhiko Sago, Satoshi Hayashi, Toshiro Honna, Morihiro Saeki

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Purpose: To investigate the clinical features and pathologic diagnosis of prenatally diagnosed lung diseases. Materials and Methods: The medical records of 28 fetuses with prenatally diagnosed lung diseases were reviewed with regard to perinatal courses, ultrasonographic measurement of the lesion volume ratio, and the histopathology of lung tissue. Results: Of the 23 fetuses with a prenatal diagnosis of congenital cystic adenomatoid malformation (CCAM), 4 required an emergency lobectomy (1 prenatally and 3 postnatally), whereas the other 14 showed uneventful courses after birth. The pathologic diagnosis of the resected lungs included CCAM (n = 4), lobar emphysema (n = 2), intralobar sequestration (n = 2), and bronchial atresia (n = 1). The peak value of the lesion volume ratio was significantly higher in the CCAM cases that required urgent surgery than in the non-CCAM cases (2.29 ± 0.46 vs 1.20 ± 0.21, P < .001). The ratio decreased after the 25th to the 30th week to less than 1.0 in the 5 non-CCAM cases, but remained higher than 2.0 in the 4 CCAM cases. Prenatally diagnosed extralobar pulmonary sequestration caused massive pleural effusion requiring a fetal intervention in 4 of the 5 fetuses. Conclusions: The prenatally diagnosed lung lesions include various kinds of pulmonary diseases. Regardless of the diseases, sequential ultrasonographic assessment may predict perinatal risks.

Original languageEnglish
Pages (from-to)2028-2031
Number of pages4
JournalJournal of Pediatric Surgery
Issue number12
Publication statusPublished - 2006 Dec 1
Externally publishedYes


  • CCAM
  • Lung diseases
  • Prenatal diagnosis
  • Pulmonary sequestration

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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