Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo

Alice Anne De Maximy, Yuhki Nakatake, Stephane Moncada, Nobuyuki Itoh, Jean Paul Thiery, Saverio Bellusci

Research output: Contribution to journalArticlepeer-review

162 Citations (Scopus)


Signaling molecules belonging to the Fibroblast growth factor (Fgf) family are necessary for directing bud outgrowth during tracheal development in Drosophila and lung development in mouse. A potential inhibitor of the Fgf signaling pathway, called Sprouty, has been identified in Drosophila. We have identified three potential mouse homologues of sprouty. One of them, called Sprouty4, exhibits a very restricted expression pattern. At 8.0 dpc (days post coitum) Sprouty4 is strongly expressed in the primitive streak region. At 9.5 and 10.5 dpc, Sprouty4 is expressed in the nasal placode, the maxillary and mandibular processes, the otic vesicule, the second branchial arch, in the progress region of the limb buds and the presomitic mesoderm. Sprouty4 expression is also detected in the lateral region of the somites. In the developing lung, Sprouty4 is expressed broadly in the distal mesenchyme.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalMechanisms of Development
Issue number1-2
Publication statusPublished - 1999 Mar 1
Externally publishedYes


  • Branching morphogenesis
  • Fibroblast growth factor
  • Lung development
  • Mouse embryo
  • Sprouty

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology


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