TY - JOUR
T1 - Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing Leucine-Rich Repeat (LRR)
AU - Nagasawa, Akemi
AU - Kubota, Ryo
AU - Imamura, Yutaka
AU - Nagamine, Kentaro
AU - Wang, Yimin
AU - Asakawa, Shuichi
AU - Kudoh, Jun
AU - Minoshima, Shinsei
AU - Mashima, Yukihiko
AU - Oguchi, Yoshihisa
AU - Shimizu, Nobuyoshi
N1 - Funding Information:
The authors thank Ms. Harumi Harigai for her assistance in manuscript preparation and Mr. Kazuhiko Kawasaki for helpful discussion about the immunoglobulin superfamily. This work was supported in part by a Grant-in-Aid for Scienti®c Research on Priority Areas from the Ministry of Education, Science, Sports and Culture of Japan; a fund from the Research Committee on Chorioretinal Degenerations, the Ministry of Health and Welfare of Japan; and a fund for the ``Research for the Future'' Program from the Japan Society for the Promotion of Science (JSPS).
PY - 1997/9/15
Y1 - 1997/9/15
N2 - We isolated cDNAs for a novel protein with a calculated molecular mass of 46 kDa, containing a leucinerich repeat (LRR) with conserved flanking sequences and a C2-type immunoglobulin (Ig)-like domain. This novel protein was considered to be a new member of the Ig superfamily and was named ISLR (immunoglobulin superfamily containing LRR). These domains are known to be important for protein-protein interaction or cell adhesion, and therefore it is possible that the novel protein ISLR may also interact with other proteins or cells. Northern blot analysis showed the presence of a 2 4-kb transcript in various human tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach, and spinal cord as well as fetal lung and fetal kidney. The ISLR gene was mapped on human chromosome 15q23-q24 by fluorescence in situ hybridization.
AB - We isolated cDNAs for a novel protein with a calculated molecular mass of 46 kDa, containing a leucinerich repeat (LRR) with conserved flanking sequences and a C2-type immunoglobulin (Ig)-like domain. This novel protein was considered to be a new member of the Ig superfamily and was named ISLR (immunoglobulin superfamily containing LRR). These domains are known to be important for protein-protein interaction or cell adhesion, and therefore it is possible that the novel protein ISLR may also interact with other proteins or cells. Northern blot analysis showed the presence of a 2 4-kb transcript in various human tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach, and spinal cord as well as fetal lung and fetal kidney. The ISLR gene was mapped on human chromosome 15q23-q24 by fluorescence in situ hybridization.
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U2 - 10.1006/geno.1997.4889
DO - 10.1006/geno.1997.4889
M3 - Article
C2 - 9325048
AN - SCOPUS:0031572321
SN - 0888-7543
VL - 44
SP - 273
EP - 279
JO - Genomics
JF - Genomics
IS - 3
ER -