Cofilin promotes vasculogenic mimicry by regulating the actin cytoskeleton in human breast cancer cells

Minami Nakajima, Ryota Kawahara, Siro Simizu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Vasculogenic mimicry (VM) is the formation of microvascular channels by cancer cells. VM requires cellular processes that are regulated by changes in cellular migration and morphology. Cofilin (CFL), a key regulator of actin depolymerization, has been reported to affect malignant phenotypes of cancer. We show that treatment with inhibitors of actin dynamics suppresses VM in MDA-MB-231 human breast cancer cells. We established CFL-knockout (KO) MDA-MB-231 cells and found that VM was attenuated in CFL-KO cells. Although the re-expression of wild-type CFL restored VM in CFL-KO cells, inactive phosphomimetic CFL failed to do so. Collectively, our results demonstrate that CFL is a critical regulator of VM and implicate CFL as a novel therapeutic target for breast cancer.

Original languageEnglish
Pages (from-to)1114-1124
Number of pages11
JournalFEBS Letters
Volume597
Issue number8
DOIs
Publication statusPublished - 2023 Apr

Keywords

  • actin cytoskeleton
  • breast cancer
  • cofilin
  • cytochalasin
  • jasplakinolide
  • vasculogenic mimicry

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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