Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature

Takahiro Yokose, Hideaki Obara, Masahiro Shinoda, Yutaka Nakano, Minoru Kitago, Hiroshi Yagi, Yuta Abe, Yohei Yamada, Kentaro Matsubara, Go Oshima, Shutaro Hori, Sho Ibuki, Hisanobu Higashi, Yuki Masuda, Masanori Hayashi, Takehiko Mori, Miho Kawaida, Takumi Fujimura, Ken Hoshino, Kaori KameyamaTatsuo Kuroda, Yuko Kitagawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


BACKGROUND Cytomegalovirus (CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia (AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation (LDLT). CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy (GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE. CONCLUSION This case report suggests a monitoring method that could be useful for AG-negative CMV gastroenteritis after a solid-organ transplantation.

Original languageEnglish
Pages (from-to)1899-1906
Number of pages8
JournalWorld Journal of Gastroenterology
Issue number15
Publication statusPublished - 2019


  • Antigenemia negative
  • Case report
  • Colon perforation
  • Cytomegalovirus gastrointestinal disease
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology


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