Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development

Maiko Wakita; Hitomi I. Sano; Yasuhiro Naito; Masaru Tomita

doi:10.22489/cinc.2016.314-180

Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development

Maiko Wakita, Hitomi I. Sano, Yasuhiro Naito, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

During rodent ventricular cell development, the sarcoplasmic reticulum (SR) is scarce and poorly organized. A Ca²⁺ transient in embryonic ventricular cells depends mostly on Ca²⁺ influx through L-type Ca²⁺ channels. In rat ventricular cells, transverse tubules (t-tubules) begin to form postnatally. As such, Ca²⁺-induced Ca²⁺ release (CICR), in which ryanodine receptor channels on the SR are activated via Ca²⁺ influx through L-type Ca²⁺ channels on the t-tubules, is not established in embryonic ventricular cells. Here, we modeled developmental changes in Guinea pig ventricular cells and identified the factors that enhance contraction of the cells with an increase in CICR.

Original language	English
Title of host publication	Computing in Cardiology Conference, CinC 2016
Editors	Alan Murray
Publisher	IEEE Computer Society
Pages	1093-1096
Number of pages	4
ISBN (Electronic)	9781509008964
DOIs	https://doi.org/10.22489/cinc.2016.314-180
Publication status	Published - 2016 Mar 1
Event	43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada Duration: 2016 Sept 11 → 2016 Sept 14

Publication series

Name	Computing in Cardiology
Volume	43
ISSN (Print)	2325-8861
ISSN (Electronic)	2325-887X

Other

Other	43rd Computing in Cardiology Conference, CinC 2016
Country/Territory	Canada
City	Vancouver
Period	16/9/11 → 16/9/14

ASJC Scopus subject areas

Computer Science(all)
Cardiology and Cardiovascular Medicine

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10.22489/cinc.2016.314-180

Cite this

Wakita, M., Sano, H. I., Naito, Y., & Tomita, M. (2016). Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development. In A. Murray (Ed.), Computing in Cardiology Conference, CinC 2016 (pp. 1093-1096). Article 7868937 (Computing in Cardiology; Vol. 43). IEEE Computer Society. https://doi.org/10.22489/cinc.2016.314-180

Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development. / Wakita, Maiko; Sano, Hitomi I.; Naito, Yasuhiro et al.
Computing in Cardiology Conference, CinC 2016. ed. / Alan Murray. IEEE Computer Society, 2016. p. 1093-1096 7868937 (Computing in Cardiology; Vol. 43).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wakita, M, Sano, HI, Naito, Y & Tomita, M 2016, Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development. in A Murray (ed.), Computing in Cardiology Conference, CinC 2016., 7868937, Computing in Cardiology, vol. 43, IEEE Computer Society, pp. 1093-1096, 43rd Computing in Cardiology Conference, CinC 2016, Vancouver, Canada, 16/9/11. https://doi.org/10.22489/cinc.2016.314-180

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AB - During rodent ventricular cell development, the sarcoplasmic reticulum (SR) is scarce and poorly organized. A Ca2+ transient in embryonic ventricular cells depends mostly on Ca2+ influx through L-type Ca2+ channels. In rat ventricular cells, transverse tubules (t-tubules) begin to form postnatally. As such, Ca2+-induced Ca2+ release (CICR), in which ryanodine receptor channels on the SR are activated via Ca2+ influx through L-type Ca2+ channels on the t-tubules, is not established in embryonic ventricular cells. Here, we modeled developmental changes in Guinea pig ventricular cells and identified the factors that enhance contraction of the cells with an increase in CICR.

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Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development

Abstract

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