Combined hepatocellular carcinoma and cholangiocarcinoma: Clinical features and computed tomographic findings

Kazunori Aoki, Kenichi Takayasu, Toshinobu Kawano, Yukio Muramatsu, Noriyuki Moriyama, Fumihiko Wakao, Junji Yamamoto, Kazuaki Shimada, Tadatoshi Takayama, Tomoo Kosuge, Susumu Yamasaki, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)


Clinicoradiological features were studied in 20 patients with 22 mass lesions of combined hepatocellular carcinoma and cholangiocarcinomas and findings of computed tomography in 12 of these patients with 14 hepatocellular carcinoma–cholangiocarcinomas. Five of these patients also had single overt hepatocellular carcinomas. The incidence of hepatocellular carcinoma–cholangiocarcinoma was 3.3% among the patients with primary liver cancer treated in our hospital. HBsAg was present in 25%, and increased levels of serum α‐fetoprotein ( > 200 ng/ml) and carcinoembryonic antigen ( > 5 ng/ml) were found in 25% and in 47%, respectively. Associated cirrhosis was present in 60%. Analysis of 14 hepatocellular carcinoma–cholangiocarcinomas in 12 patients in whom the enhancement pattern on dynamic computed tomography and pathological findings could be studied and compared suggested three tumor types. Nine lesions (type A) were demonstrated only as areas with high‐density peripheries in the early phase of enhancement that evolved into a pattern of peripheral low density and central high density in the late phase. Four masses (type B) were shown as hyperdense tumors (early phase) that changed to low density in the late phase. One mass (type C) was seen as a low‐density lesion that did not change. Histopathologically, type A comprised hepatocellular carcinoma–predominant components in the peripheral area, cholangiocarcinoma‐predominant components with abundant fibrous stroma in the central area and a tissue transitional between the two in the midzone. By contrast, two of four type B masses comprised hepatocellular carcinoma with scattered cholangiocarcinoma components throughout the tumor. The remaining two masses had main nodules of hepatocellular carcinoma and adherent small cholangiocarcinomas. One type C mass had a main cholangiocarcinoma nodule and an adjacent small hepatocellular carcinoma. Differentiation of hepatocellular carcinoma–cholangiocarcinoma from hepatocellular carcinoma or cholangiocarcinoma with computed tomography alone was difficult. When computed tomography results and α‐fetoprotein or carcinoembryonic antigen levels show some discrepancy, the possibility of hepatocellular carcinoma–cholangiocarcinoma should be considered. (HEPATOLOGY 1993;18:1090‐1095).

Original languageEnglish
Pages (from-to)1090-1095
Number of pages6
Issue number5
Publication statusPublished - 1993 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology


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