Comparison of White Matter Structure of Drug-Naïve Patients With Bipolar Disorder and Major Depressive Disorder Using Diffusion Tensor Tractography

Akihiro Koreki, Richi Niida, Akira Niida, Bun Yamagata, Sachiko Anamizu, Masaru Mimura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: The presence of microstructural white matter (WM) abnormalities in individuals with bipolar disorder (BD) has previously been reported. However, the interpretation of data is challenging because pharmacological treatment has a potential effect on WM integrity. To date, no study has compared the differences in WM structure among drug-naïve BD patients, drug-naïve major depression disorder (MDD) patients, and healthy controls (HC) using the visual evaluation method of diffusion tensor tractography (DTT). Methods: This retrospective study included 12 drug-naïve patients with BD, 15 drug-naïve patients with MDD, and 27 age- and sex-matched HC individuals. Visual evaluation, fractional anisotropy (FA), and apparent diffusion coefficient (ADC) were analysed in the anterior thalamic radiation (ATR) as a tract of interest using the optimal follow-up truncation threshold. They were also analysed in the cingulate fasciculus, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, and fornix. Results: No significant differences were found in the FA or ADC of any tract. However, visual evaluation revealed poorer depiction of ATR in patients with BD than in patients with MDD and HC individuals (p = 0.004). Our post-hoc analysis showed a significant difference between BD and HC patients (p = 0.018). Conclusions: The visual evaluation method of DTT revealed poor depiction of ATR in patients with BD compared with HC individuals and MDD patients, suggesting microstructural WM abnormalities of ATR in BD.

Original languageEnglish
Article number714502
JournalFrontiers in Psychiatry
Volume12
DOIs
Publication statusPublished - 2022 Feb 14

Keywords

  • anterior thalamic radiation
  • bipolar disorder
  • diffusion tensor tractography
  • major depressive disorder
  • white matter

ASJC Scopus subject areas

  • Psychiatry and Mental health

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