Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Kazuhiko Nakamura; Yu Tachikawa; Makoto Kitamura; Osamu Ohno; Masami Suganuma; Daisuke Uemura

doi:10.1039/b803107j

Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Kazuhiko Nakamura, Yu Tachikawa, Makoto Kitamura, Osamu Ohno, Masami Suganuma, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

Original language	English
Pages (from-to)	2058-2060
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	6
Issue number	12
DOIs	https://doi.org/10.1039/b803107j
Publication status	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/b803107j

Cite this

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abstract = "The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.",

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AU - Nakamura, Kazuhiko

AU - Tachikawa, Yu

AU - Kitamura, Makoto

AU - Ohno, Osamu

AU - Suganuma, Masami

AU - Uemura, Daisuke

PY - 2008

Y1 - 2008

N2 - The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

AB - The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

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Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Abstract

ASJC Scopus subject areas

UN SDGs

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